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10.1016/j.nbd.2014.07.012 http://scihub22266oqcxt.onion/10.1016/j.nbd.2014.07.012 C5589075!5589075!25102344     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurobiol+Dis 2014 ; 71 (ä): 215-9 Nephropedia Template TP {{tp|p=25102344|t=2014. Evidence for Lymphatic A? Clearance in Alzheimer?s Transgenic Mice |pdf=|usr=}}{{25102344}} gab.com Text Evidence for Lymphatic A Clearance in Alzheimer s Transgenic Mice JO: Neurobiol Dis http://www.kidney.de/pget.php?&tw=1&pmid=25102344 #FOAvip Evidence has shown that lymphatic drainage contributes to removal of debris from the brain but its role in the accumulation of amyloid ? peptides (A?) has not been demonstrated. We examined the levels of various forms of A? in the brain, plasma and lymph nodes in a transgenic model of Alzheimer?s disease (AD) at different ages. Herein, we report on the novel finding that A? is present in the cervical and axillary lymph nodes of AD transgenic mice and that A? levels in lymph nodes increase over time, mirroring the increase of A? levels observed in the brain. A? levels in lymph nodes were significantly higher than in plasma. At age 15.5 months, there was a significant increase of monomeric soluble A?40 (p=0.003) and A?42 (p=0.05) in the lymph nodes over the baseline values measured at 6 months of age. In contrast, plasma levels of A?40 showed no significant changes (p=0.68) and plasma levels A?42 significantly dropped (p=0.02) at the same age. A? concentration was low to undetectable in splenic lymphoid tissue and several other control tissues including heart, lung, liver, kidneys and intestine of the same animals, strongly suggesting that A? peptides in lymph nodes are derived from the brain. Twit Text FOAVip Evidence for Lymphatic A Clearance in Alzheimer s Transgenic Mice ????Neurobiol Dis http://www.kidney.de/pget.php?&tw=1&pmid=25102344 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25102344 #FOAvip English Wikipedia <ref>{{Cite pmid|25102344}}</ref> Evidence for Lymphatic A? Clearance in Alzheimer?s Transgenic Mice #MMPMID25102344 Pappolla M; Sambamurti K; Vidal R; Pacheco-Quinto J; Poeggeler B; Matsubara E Neurobiol Dis 2014[Nov]; 71 (ä): 215-9 PMID25102344show ga Evidence has shown that lymphatic drainage contributes to removal of debris from the brain but its role in the accumulation of amyloid ? peptides (A?) has not been demonstrated. We examined the levels of various forms of A? in the brain, plasma and lymph nodes in a transgenic model of Alzheimer?s disease (AD) at different ages. Herein, we report on the novel finding that A? is present in the cervical and axillary lymph nodes of AD transgenic mice and that A? levels in lymph nodes increase over time, mirroring the increase of A? levels observed in the brain. A? levels in lymph nodes were significantly higher than in plasma. At age 15.5 months, there was a significant increase of monomeric soluble A?40 (p=0.003) and A?42 (p=0.05) in the lymph nodes over the baseline values measured at 6 months of age. In contrast, plasma levels of A?40 showed no significant changes (p=0.68) and plasma levels A?42 significantly dropped (p=0.02) at the same age. A? concentration was low to undetectable in splenic lymphoid tissue and several other control tissues including heart, lung, liver, kidneys and intestine of the same animals, strongly suggesting that A? peptides in lymph nodes are derived from the brain. äEvidence for Lymphatic A? Clearance in Alzheimer?s Transgenic Mice (epmc).pdf DeepDyve Pubget Overpricing