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10.1016/j.celrep.2017.07.058 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.07.058 C5588873!5588873!28813667     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2017 ; 20 (7): 1543-52 Nephropedia Template TP {{tp|p=28813667|t=2017. Human GW182 Paralogs are the Central Organizers for RNA-Mediated Control of Transcription |pdf=|usr=}}{{28813667}} gab.com Text Human GW182 Paralogs are the Central Organizers for RNA-Mediated Control of Transcription JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28813667 #FOAvip In the cytoplasm, small RNAs can control mammalian translation by regulating the stability of mRNA. In the nucleus, small RNAs can also control transcription and splicing. The mechanisms for RNA-mediated nuclear regulation are not understood and remain controversial, hindering the effective application of nuclear RNAi and blinding investigation of its natural regulatory roles. Here we reveal that the human GW182 paralogs TNRC6A/B/C are central organizing factors critical to RNA-mediated transcriptional activation. Mass spectrometry of purified nuclear lysates followed by experimental validation demonstrates that TNRC6A interacts with proteins involved in protein degradation, RNAi, the CCR4-NOT complex, the mediator complex, and histone modifying complexes. Functional analysis implicates TNRC6A, NAT10, MED14, and WDR5 in RNA-mediated transcriptional activation. These findings describe protein complexes capable of bridging RNA-mediated sequence-specific recognition of noncoding RNA transcripts with the regulation of gene transcription. Twit Text FOAVip Human GW182 Paralogs are the Central Organizers for RNA-Mediated Control of Transcription ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28813667 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28813667 #FOAvip English Wikipedia <ref>{{Cite pmid|28813667}}</ref> Human GW182 Paralogs are the Central Organizers for RNA-Mediated Control of Transcription #MMPMID28813667 Hicks JA; Li L; Matsui M; Chu Y; Volkov O; Johnson KC; Corey DR Cell Rep 2017[Aug]; 20 (7): 1543-52 PMID28813667show ga In the cytoplasm, small RNAs can control mammalian translation by regulating the stability of mRNA. In the nucleus, small RNAs can also control transcription and splicing. The mechanisms for RNA-mediated nuclear regulation are not understood and remain controversial, hindering the effective application of nuclear RNAi and blinding investigation of its natural regulatory roles. Here we reveal that the human GW182 paralogs TNRC6A/B/C are central organizing factors critical to RNA-mediated transcriptional activation. Mass spectrometry of purified nuclear lysates followed by experimental validation demonstrates that TNRC6A interacts with proteins involved in protein degradation, RNAi, the CCR4-NOT complex, the mediator complex, and histone modifying complexes. Functional analysis implicates TNRC6A, NAT10, MED14, and WDR5 in RNA-mediated transcriptional activation. These findings describe protein complexes capable of bridging RNA-mediated sequence-specific recognition of noncoding RNA transcripts with the regulation of gene transcription. äHuman GW182 Paralogs are the Central Organizers for RNA-Mediated Contr(epmc).pdf DeepDyve Pubget Overpricing