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10.3762/bjoc.13.178 http://scihub22266oqcxt.onion/10.3762/bjoc.13.178 C5588497!5588497!28904627     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28904627&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Beilstein+J+Org+Chem 2017 ; 13 (ä): 1828-49 Nephropedia Template TP {{tp|p=28904627|t=2017. Mechanochemical synthesis of thioureas, ureas and guanidines |pdf=|usr=}}{{28904627}} gab.com Text Mechanochemical synthesis of thioureas, ureas and guanidines JO: Beilstein J Org Chem http://www.kidney.de/pget.php?&tw=1&pmid=28904627 #FOAvip In this review, the recent progress in the synthesis of ureas, thioureas and guanidines by solid-state mechanochemical ball milling is highlighted. While the literature is abundant on their preparation in conventional solution environment, it was not until the advent of solvent-free manual grinding using a mortar and pestle and automated ball milling that new synthetic opportunities have opened. The mechanochemical approach not only has enabled the quantitative synthesis of (thio)ureas and guanidines without using bulk solvents and the generation of byproducts, but it has also been established as a means to develop "click-type" chemistry for these classes of compounds and the concept of small molecule desymmetrization. Moreover, mechanochemistry has been demonstrated as an effective tool in reaction discovery, with emphasis on the reactivity differences in solution and in the solid state. These three classes of organic compounds share some structural features which are reflected in their physical and chemical properties, important for application as organocatalysts and sensors. On the other hand, the specific and unique nature of each of these functionalities render (thio)ureas and guanidines as the key constituents of pharmaceuticals and other biologically active compounds. Twit Text FOAVip Mechanochemical synthesis of thioureas, ureas and guanidines ????Beilstein J Org Chem http://www.kidney.de/pget.php?&tw=1&pmid=28904627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28904627 #FOAvip English Wikipedia <ref>{{Cite pmid|28904627}}</ref> Mechanochemical synthesis of thioureas, ureas and guanidines #MMPMID28904627 ?trukil V Beilstein J Org Chem 2017[]; 13 (ä): 1828-49 PMID28904627show ga In this review, the recent progress in the synthesis of ureas, thioureas and guanidines by solid-state mechanochemical ball milling is highlighted. While the literature is abundant on their preparation in conventional solution environment, it was not until the advent of solvent-free manual grinding using a mortar and pestle and automated ball milling that new synthetic opportunities have opened. The mechanochemical approach not only has enabled the quantitative synthesis of (thio)ureas and guanidines without using bulk solvents and the generation of byproducts, but it has also been established as a means to develop "click-type" chemistry for these classes of compounds and the concept of small molecule desymmetrization. Moreover, mechanochemistry has been demonstrated as an effective tool in reaction discovery, with emphasis on the reactivity differences in solution and in the solid state. These three classes of organic compounds share some structural features which are reflected in their physical and chemical properties, important for application as organocatalysts and sensors. On the other hand, the specific and unique nature of each of these functionalities render (thio)ureas and guanidines as the key constituents of pharmaceuticals and other biologically active compounds. äMechanochemical synthesis of thioureas, ureas and guanidines (epmc).pdf DeepDyve Pubget Overpricing