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10.1159/000439350

http://scihub22266oqcxt.onion/10.1159/000439350
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C5588285!5588285!26380973
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suck abstract from ncbi


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pmid26380973      Med+Princ+Pract 2015 ; 24 (6): 581-3
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  • Severe Methanol Poisoning with Supralethal Serum Formate Concentration: A Case Report #MMPMID26380973
  • Nurieva O; Kotikova K
  • Med Princ Pract 2015[Oct]; 24 (6): 581-3 PMID26380973show ga
  • Objective: To present a case of survival without visual and central nervous system sequelae at a formate concentration of twice the reported lethal level. Clinical Presentation and Intervention: This was a case of a 33-year-old man who ingested 1 liter of a toxic mixture of methanol and ethanol. Upon admission, he presented with anxiety, tachycardia and hypertension and had a serum formate level of 1,400 mg/l (normal range 0.9?2.1 mg/l), a methanol level of 806 mg/l (normal range 2?30 mg/l), an undetectable ethanol concentration and a normal lactate level. A 10% solution of ethanol and folinic acid was administered intravenously and two 8-hour sessions of intermittent hemodialysis were performed. The patient was discharged on the fifth day without sequelae of poisoning. The follow-up examinations 3 months and 2 years later revealed no damage to the basal ganglia. The patient had normal visual-evoked potential and findings on optical coherence tomography. The genetic analysis revealed a rare minor allele for the gene coding CYP2E1 enzyme of the microsomal ethanol oxidizing system. Conclusion: The patient survived acute methanol poisoning without long-term sequelae despite a high serum level of formic acid upon admission.
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