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2017 ; 14
(3
): 2663-2668
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Loss of fibulin-2 expression is involved in the inhibition of breast cancer
invasion and forms a new barrier in addition to the basement membrane
#MMPMID28928811
Tan H
; Zhang J
; Fu D
; Zhu Y
Oncol Lett
2017[Sep]; 14
(3
): 2663-2668
PMID28928811
show ga
Previous studies have demonstrated that fibulin-2 may facilitate cancer cell
invasion and metastasis during tumor progression. In the present study,
immunohistochemical analyses of fibulin-2 and collagen IV expression in 35
patients with breast cancer were performed to define their localization and
association with breast cancer tissue. Fibulin-2 was revealed to be expressed in
all tissues surrounding the breast ducts and blood vessels in normal breast
tissue, while its expression was not integrated in invasive ductal carcinoma or
terminal duct-lobular unit. In malignant breast tissue, collagen IV was
integrated around the duct, while fibulin-2 was expressed around collagen IV and
was incomplete. These results demonstrated that fibulin-2 was associated with
breast cancer invasion. Fibulin-2 expression decreased prior to basement membrane
(BM) degradation, indicating that fibulin-2 forms an additional barrier around
the BM. Therefore, it was proposed that fibulin-2 composes the general BM, which
differs from the traditional BM. These results provide insight into extracellular
matrix components and the involvement of fibulin-2 in tumor invasion and
metastasis. Fibulin-2 was involved in the process of breast cancer development.
It performed an important role in prevention of cancer cell penetration and
metastasis.