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10.3892/ol.2017.6475 http://scihub22266oqcxt.onion/10.3892/ol.2017.6475 C5588119!5588119 !28927053     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28927053 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncol+Lett 2017 ; 14 (3 ): 3057-3064 Nephropedia Template TP {{tp|p=28927053 |t=2017. Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents |pdf=|usr=}}{{28927053 }} gab.com Text Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28927053 #FOAvip A total of five matrine derivatives were synthesized and evaluated for their anti-proliferation activity using a panel of four human cancer cell lines, including A549 lung, BT20 breast, MCF-7 breast and U2OS osteosarcoma cells. The YF3-5, YF3-7 and YF3-9, three novel compounds, demonstrated increased anti-proliferation activity compared with matrine, of which YF3-5 revealed the strongest anti-proliferation activity with a half-maximal inhibitory concentration value of 15.49-16.67 µM against the four human cancer cell lines. The anti-proliferation mechanism underlying YF3-5 was investigated in the A549 human lung cancer cell line and the results demonstrated that YF3-5 exerted its anti-proliferation activity through the induction of apoptosis and oxidative stress, in addition to arresting the cell cycle at the G(1) phase in a dose-dependent manner. Twit Text FOAVip Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28927053 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28927053 #FOAvip English Wikipedia <ref>{{Cite pmid|28927053 }}</ref> Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents #MMPMID28927053 Jiang L ; Wu L ; Yang F ; Almosnid N ; Liu X ; Jiang J ; Altman E ; Wang L ; Gao Y Oncol Lett 2017[Sep]; 14 (3 ): 3057-3064 PMID28927053 show ga A total of five matrine derivatives were synthesized and evaluated for their anti-proliferation activity using a panel of four human cancer cell lines, including A549 lung, BT20 breast, MCF-7 breast and U2OS osteosarcoma cells. The YF3-5, YF3-7 and YF3-9, three novel compounds, demonstrated increased anti-proliferation activity compared with matrine, of which YF3-5 revealed the strongest anti-proliferation activity with a half-maximal inhibitory concentration value of 15.49-16.67 µM against the four human cancer cell lines. The anti-proliferation mechanism underlying YF3-5 was investigated in the A549 human lung cancer cell line and the results demonstrated that YF3-5 exerted its anti-proliferation activity through the induction of apoptosis and oxidative stress, in addition to arresting the cell cycle at the G(1) phase in a dose-dependent manner. äSynthesis, biological evaluation and mechanism studies of matrine deri(epmc).pdf DeepDyve Pubget Overpricing