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2017 ; 14
(3
): 2683-2690
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English Wikipedia
Prognostic significance of the epithelial-mesenchymal transition factor zinc
finger E-box-binding homeobox 2 in esophageal squamous cell carcinoma
#MMPMID28927031
Huo X
; Huo B
; Wang H
; Zhang H
; Ma Z
; Yang M
; Wang H
; Yu Z
Oncol Lett
2017[Sep]; 14
(3
): 2683-2690
PMID28927031
show ga
Zinc finger E-box-binding homeobox 2 (ZEB2) has been reported to mediate
epithelial-mesenchymal transition (EMT) and disease progression in several cancer
types. However, the expression of ZEB2 in esophageal squamous cell carcinoma
(OSCC) and its association with prognosis remains unclear. In the present study,
a tissue microarray and immunohistochemistry were used to investigate ZEB2 and
epithelial (E-)cadherin expression in OSCC tissues (n=218) and peritumoral
esophageal tissues (POT; n=60). There was a significantly increased incidence of
positive ZEB2 expression in OSCC tissues compared with the expression in POTs
(P<0.012). By contrast, the incidence of positive E-cadherin expression in OSCC
tissues was significantly decreased compared with the expression in POTs
(P<0.004). ZEB2 expression in OSCC was associated with a number of
clinicopathological factors, and it was also an independent predictive factor for
shorter overall survival time (P<0.001). Overall, ZEB2 may promote OSCC
metastasis and is a potential prognostic marker for malignancy.