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2017 ; 14
(3
): 3065-3070
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Methylation of STK11 promoter is a risk factor for tumor stage and survival in
clear cell renal cell carcinoma
#MMPMID28927054
Zheng F
; Yuan X
; Chen E
; Ye Y
; Li X
; Dai Y
Oncol Lett
2017[Sep]; 14
(3
): 3065-3070
PMID28927054
show ga
Inactivation of tumor suppressor gene serine-threonine kinase 11 (STK11) in clear
cell renal cell carcinoma (ccRCC) has been demonstrated; however, the mechanism
of this inactivation remains to be investigated. To investigate whether
epigenetic alteration plays a role in the inactivation of STK11 in RCC, the
present study aimed to investigate the methylation status of the STK11 promoter
and its association with tumor stage and survival in ccRCC patients.
Paraffin-embedded specimens were obtained from 42 ccRCC patients. The specimens
were analyzed for the methylation status of the STK11 promoter CpG island using
methylation-specific polymerase chain reaction. Survival, tumor-node-metastasis
(TNM)/American Joint Committee on Cancer (AJCC) stages, and hematological
parameters were compared between patients with unmethylated (U), partially
methylated (P) and methylated (M) STK11 promoter. Among the 42 patients, there
were 12 (28.6%), 18 (42.9%) and 12 (28.6%) patients in the M, P and U groups,
respectively. The methylation status of the STK11 promoter was associated with T,
N and AJCC stages in RCC. Survival analysis showed that the M group had a
significantly shorter survival time compared with the P and U groups. These
findings suggested that methylation of the STK11 promoter in RCC is a not rare
event, and it may have an important role in the pathogenesis of RCC and be a risk
factor for the prognosis of RCC.
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