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10.3892/ol.2017.6600

http://scihub22266oqcxt.onion/10.3892/ol.2017.6600
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C5588050!5588050!28927149
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suck abstract from ncbi


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pmid28927149      Oncol+Lett 2017 ; 14 (3): 3795-802
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  • MicroRNA-552 promotes tumor cell proliferation and migration by directly targeting DACH1 via the Wnt/?-catenin signaling pathway in colorectal cancer #MMPMID28927149
  • Cao J; Yan XR; Liu T; Han XB; Yu JJ; Liu SH; Wang LB
  • Oncol Lett 2017[Sep]; 14 (3): 3795-802 PMID28927149show ga
  • The purpose of the present study was to analyze the crucial role of microRNAs (miRNAs/miRs) involved in the proliferation and migration of colorectal cancer (CRC) and to investigate their underlying mechanisms. The present study discusses the expression and function of miR-552 in CRC. The expression level of miR-552 in CRC cells and tissues was observed, and it was suggested that the high expression of miR-552 accelerated the proliferation and migration of CRC cells in vitro. Notably, a result of the present study was that the cell fate determination factor Dachshund family transcription factor 1 (DACH1) was identified as a direct target of miR-552. Suppressing miR-552 expression in CRC cells increased endogenous DACH1 mRNA and protein levels, which was negatively correlated with miR-552. DACH1 performs an important role in the development of a number of neoplasms, and has the ability to regulate the Wnt/?-catenin signaling pathway as a novel predictive and diagnostic biomarker. Accordingly, it was concluded that miR-552 exerted a tumor-promoting role in CRC development by targeting DACH1, which may contribute to the increase in the rates of CRC proliferation and migration. miR-552 may serve as a potential diagnostic and prognostic biomarker for CRC.
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