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2017 ; 14
(3
): 3657-3662
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Vascular endothelial growth factor and protein level in pleural effusion for
differentiating malignant from benign pleural effusion
#MMPMID28927127
Wu DW
; Chang WA
; Liu KT
; Yen MC
; Kuo PL
Oncol Lett
2017[Sep]; 14
(3
): 3657-3662
PMID28927127
show ga
Pleural effusion is associated with multiple benign and malignant conditions.
Currently no biomarkers differentiate malignant pleural effusion (MPE) and benign
pleural effusion (BPE) sensitively and specifically. The present study identified
a novel combination of biomarkers in pleural effusion for differentiating MPE
from BPE by enrolling 75 patients, 34 with BPE and 41 with MPE. The levels of
lactate dehydrogenase, glucose, protein, and total cell, neutrophil, monocyte and
lymphocyte counts in the pleural effusion were measured. The concentrations of
interleukin (IL)-1?, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, tumor necrosis
factor-?, interferon ?, transforming growth factor-?1, colony stimulating factor
2, monocyte chemoattractant protein-1 and vascular endothelial growth factor
(VEGF) were detected using cytometric bead arrays. Protein and VEGF levels
differed significantly between patients with BPE and those with MPE. The optimal
cutoff value of VEGF and protein was 214 pg/ml and 3.35 g/dl respectively,
according to the receiver operating characteristic curve. A combination of VEGF
>214 pg/ml and protein >3.35 g/dl in pleural effusion presented a sensitivity of
92.6% and an accuracy of 78.6% for MPE, but was not associated with a decreased
survival rate. These results suggested that this novel combination strategy may
provide useful biomarkers for predicting MPE and facilitating early diagnosis.