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2017 ; 14
(3
): 3291-3296
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English Wikipedia
Yes-associated protein: A novel molecular target for the diagnosis, treatment and
prognosis of hepatocellular carcinoma
#MMPMID28927078
Shan L
; Jiang H
; Ma L
; Yu Y
Oncol Lett
2017[Sep]; 14
(3
): 3291-3296
PMID28927078
show ga
Hepatocellular carcinoma (HCC) is a common type of malignant tumor. The
early-diagnosis and treatment options for HCC are limited, which is primarily due
to an incomplete understanding of the underlying molecular mechanisms of the
disease. Yes-associated protein (YAP) overexpression promotes proliferation and
phenotypic transformation of HCC cells. Recently, elucidating the molecular
mechanisms of the Hippo/YAP signaling pathway and investigating the interactions
between the signaling molecules, as a potential strategy for the treatment of
HCC, has become an area of interest. The present review will discuss the role of
YAP in HCC pathogenesis, and the significance of YAP in diagnosis, treatment and
determining the prognosis.