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2017 ; 14
(3
): 3429-3436
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Inhibition of LHX2 by miR-124 suppresses cellular migration and invasion in
non-small cell lung cancer
#MMPMID28927097
Yang Q
; Wan L
; Xiao C
; Hu H
; Wang L
; Zhao J
; Lei Z
; Zhang HT
Oncol Lett
2017[Sep]; 14
(3
): 3429-3436
PMID28927097
show ga
Downregulated microRNA (miR)-124 is common in numerous types of cancer, including
non-small cell lung cancer (NSCLC). A previous study by the authors demonstrated
that LIM-homeobox domain 2 (LHX2) was upregulated and promoted cell growth in
NSCLC. However, whether LHX2 affects the migratory and invasive abilities of
NSCLC cells and the association of LHX2 with miR-124 remains unclear. The present
study revealed that miR-124 expression was frequently decreased in human NSCLC
cells and tissues and negatively correlated with LHX2 expression, which was
increased in NSCLC cells and tissues. Furthermore, the transfection of miR-124
mimic significantly inhibited endogenous expression of LHX2 mRNA and protein in
A549 and H1299 cells, and miR-124 inhibitor promoted LHX2 expression. Of note,
overexpression of miR-124 in A549 and H1299 cells attenuated cellular migratory
and invasive abilities, and this was observed in LHX2-silenced A549 and H1299
cells. Knockdown of miR-124 augmented the migratory and invasive abilities in
A549 and H1299 cells. The 3'-untranslated region of LHX2 transcript has also been
identified to be a putative target of miR-124. Taken together, the results
revealed that miR-124 may inhibit migration and invasion by repressing LHX2
expression in NSCLC cells. The findings of the present study suggested that
overexpression of miR-124 or silencing of LHX2 may provide a therapeutic strategy
for advanced NSCLC.
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