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2017 ; 14
(3
): 3235-3242
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MicroRNA-452 suppresses pancreatic cancer migration and invasion by directly
targeting B-cell-specific Moloney murine leukemia virus insertion site 1
#MMPMID28927071
Li H
; Wu Y
; Li P
Oncol Lett
2017[Sep]; 14
(3
): 3235-3242
PMID28927071
show ga
Pancreatic cancer, one of the most common cancers globally, is the fourth most
common cause of cancer-associated mortality in the USA. The 5-year relative
survival rate for patients with pancreatic cancer is ~5% and the median survival
time is only 6 months. The poor prognosis is mainly due to early and aggressive
local invasion and metastasis, as well as dissemination of the pancreatic cancer
cells. The present study demonstrated that microRNA-452 (miR-452) was markedly
downregulated in pancreatic cancer tissues, particularly in metastatic tumors and
pancreatic cancer cell lines. Overexpression of miR-452 significantly inhibited
migration and invasion in pancreatic cancer cells. In addition, the molecular
mechanism underlying the inhibitory functions of miR-452 in pancreatic cancer was
also investigated. The results indicated that B-cell-specific Moloney murine
leukemia virus insertion site 1 (BMI1) was a direct target gene of miR-452 in
pancreatic cancer. Overexpression of miR-452 inhibited the migration and invasion
of pancreatic cancer, at least partially by knockdown of BMI1 expression. The
results provided novel insight with potential therapeutic applications for the
treatment of metastatic pancreatic cancer.
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