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2017 ; 7
(1
): 10694
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English Wikipedia
Effects of Intensive Blood Pressure Reduction on Acute Intracerebral Hemorrhage:
A Systematic Review and Meta-analysis
#MMPMID28878305
Gong S
; Lin C
; Zhang D
; Kong X
; Chen J
; Wang C
; Li Z
; Chen R
; Sheng P
; Dong Y
; Hou L
Sci Rep
2017[Sep]; 7
(1
): 10694
PMID28878305
show ga
Current opinions about the effect of intensive blood pressure (BP) reduction for
acute intracerebral hemorrhage (ICH) are inconsistent. We performed a
meta-analysis to evaluate the efficacy and safety of intensive BP reduction for
acute ICH by analyzing data from several recent randomized controlled trials
(RCTs). There were six eligible studies that met the inclusion criteria, for a
total of 4,385 acute ICH patients in this meta-analysis. After analyzing these
data, we found differences between intensive and standard BP lowering treatment
groups in total mortality rates, unfavorable outcomes, hematoma expansion,
neurologic deterioration, and severe hypotension were not significant. Moreover,
compared with the standard treatment, the rate of renal adverse event in
intensive treatment group was significantly higher. The intensive treatment
approach was recommended in the following situations: (1) longer prehospital
duration; (2) lower National Institute of Health stroke scale (NIHSS) score; (3)
no hypertension history.
|Age Factors
[MESH]
|Antihypertensive Agents/pharmacology/*therapeutic use
[MESH]