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10.1038/s41598-017-11089-0 http://scihub22266oqcxt.onion/10.1038/s41598-017-11089-0 C5587788!5587788 !28878231     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28878231 &cmd=llinks): Failed to open stream: HTTP request failed! 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Dietary iron restriction alleviates renal tubulointerstitial injury induced by protein overload in mice |pdf=|usr=}}{{28878231 }} gab.com Text Dietary iron restriction alleviates renal tubulointerstitial injury induced by protein overload in mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28878231 #FOAvip Increased proteinuria causes tubulointerstitial injury due to inflammation in chronic kidney disease (CKD). Iron restriction exhibits protective effects against renal dysfunction; however, its effects against protein overload-induced tubulointerstitial damage remain unclear. Here, we investigated dietary iron restriction effect on tubulointerstitial damage in mice with protein-overload tubulointerstitial injury. Renal tubulointerstitial injury in animal model was induced by intraperitoneal injection of an overdose of bovine serum albumin (BSA). We divided mice into three groups: normal saline?+?normal diet (ND), BSA?+?ND, and BSA?+?iron-restricted diet (IRD). BSA overload induced renal tubulointerstitial injury in the ND mice, which was ameliorated in the IRD mice. Inflammatory cytokines and extracellular matrix mRNA expression was upregulated in BSA?+?ND mice kidneys and was inhibited by IRD. BSA-induced increase in renal superoxide production, NADPH oxidase activity, and p22(phox) expression was diminished in the IRD mice. IRD suppression increased BSA-induced renal macrophage infiltration. Moreover, BSA mice exhibited nucleotide-binding oligomerisation domain-like receptor pyrin domain-containing protein (NLRP) inflammasome activation, which was inhibited by IRD. Ferrous iron increased in kidneys with BSA overload and was inhibited by IRD. Thus, iron restriction inhibited oxidative stress and inflammatory changes, contributing to the protective effect against BSA overload-induced tubulointerstitial injury. Twit Text FOAVip Dietary iron restriction alleviates renal tubulointerstitial injury induced by protein overload in mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28878231 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28878231 #FOAvip English Wikipedia <ref>{{Cite pmid|28878231 }}</ref> Dietary iron restriction alleviates renal tubulointerstitial injury induced by protein overload in mice #MMPMID28878231 Ikeda Y ; Horinouchi Y ; Hamano H ; Hirayama T ; Kishi S ; Izawa-Ishizawa Y ; Imanishi M ; Zamami Y ; Takechi K ; Miyamoto L ; Ishizawa K ; Aihara KI ; Nagasawa H ; Tsuchiya K ; Tamaki T Sci Rep 2017[Sep]; 7 (1 ): 10621 PMID28878231 show ga Increased proteinuria causes tubulointerstitial injury due to inflammation in chronic kidney disease (CKD). Iron restriction exhibits protective effects against renal dysfunction; however, its effects against protein overload-induced tubulointerstitial damage remain unclear. Here, we investigated dietary iron restriction effect on tubulointerstitial damage in mice with protein-overload tubulointerstitial injury. Renal tubulointerstitial injury in animal model was induced by intraperitoneal injection of an overdose of bovine serum albumin (BSA). We divided mice into three groups: normal saline?+?normal diet (ND), BSA?+?ND, and BSA?+?iron-restricted diet (IRD). BSA overload induced renal tubulointerstitial injury in the ND mice, which was ameliorated in the IRD mice. Inflammatory cytokines and extracellular matrix mRNA expression was upregulated in BSA?+?ND mice kidneys and was inhibited by IRD. BSA-induced increase in renal superoxide production, NADPH oxidase activity, and p22(phox) expression was diminished in the IRD mice. IRD suppression increased BSA-induced renal macrophage infiltration. Moreover, BSA mice exhibited nucleotide-binding oligomerisation domain-like receptor pyrin domain-containing protein (NLRP) inflammasome activation, which was inhibited by IRD. Ferrous iron increased in kidneys with BSA overload and was inhibited by IRD. Thus, iron restriction inhibited oxidative stress and inflammatory changes, contributing to the protective effect against BSA overload-induced tubulointerstitial injury. |*Iron, Dietary [MESH] |Acute Kidney Injury/diet therapy/*etiology/*metabolism/pathology [MESH] |Animals [MESH] |Biomarkers [MESH] |Cytokines/metabolism [MESH] |Disease Models, Animal [MESH] |Immunohistochemistry [MESH] |Inflammasomes/metabolism [MESH] |Inflammation Mediators/metabolism [MESH] |Iron/*metabolism [MESH] |Kidney Function Tests [MESH] |Male [MESH] |Mice [MESH] |NADPH Oxidases/metabolism [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/metabolism [MESH] |Nephritis, Interstitial/diet therapy/*etiology/*metabolism/pathology [MESH] |Oxidative Stress [MESH] |Proteinuria/*complications/*metabolism [MESH]Dietary iron restriction alleviates renal tubulointerstitial injury in(epmc).pdf DeepDyve Pubget Overpricing