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10.1371/journal.pone.0184068 http://scihub22266oqcxt.onion/10.1371/journal.pone.0184068 C5587291!5587291 !28877210     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28877210 &cmd=llinks): Failed to open stream: HTTP request failed! 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Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade |pdf=|usr=}}{{28877210 }} gab.com Text Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28877210 #FOAvip Previous data indicate that Tankyrase inhibitors exert anti-growth functions in many cancer cell lines due to their ability to inactivate the YAP protooncogene. In the present manuscript, we investigated the effect of Tankyrase inhibitors on the growth of hepatocellular carcinoma (HCC) cell lines and the molecular mechanisms involved. For this purpose, we performed cell proliferation assay by colony-forming ability in seven human HCC cells subjected to XAV-939 and G007-LK Tankyrase inhibitors. Noticeably, the two Tankyrase inhibitors suppressed the HCC cell growth in a dose-dependent manner. Furthermore, we found that Tankyrase inhibitors synergized with MEK and AKT inhibitors to suppress HCC cell proliferation. At the molecular level, Tankyrase inhibitors significantly decreased YAP protein levels, reduced the expression of YAP target genes, and inhibited YAP/TEAD luciferase reporter activity. In addition, Tankyrase inhibitors administration was accompanied by upregulation of Angiomotin-like 1 (AMOTL1) and Angiomotin-like 2 (AMOTL2) proteins, two major negative regulators of YAP. Altogether, the present data indicate that XAV-939 and G007-LK Tankyrase inhibitors could suppress proliferation of hepatocellular carcinoma cells and downregulate YAP/TAZ by stabilizing AMOTL1 and AMOTL2 proteins, thus representing new potential anticancer drugs against hepatocellular carcinoma. Twit Text FOAVip Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28877210 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28877210 #FOAvip English Wikipedia <ref>{{Cite pmid|28877210 }}</ref> Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade #MMPMID28877210 Jia J ; Qiao Y ; Pilo MG ; Cigliano A ; Liu X ; Shao Z ; Calvisi DF ; Chen X PLoS One 2017[]; 12 (9 ): e0184068 PMID28877210 show ga Previous data indicate that Tankyrase inhibitors exert anti-growth functions in many cancer cell lines due to their ability to inactivate the YAP protooncogene. In the present manuscript, we investigated the effect of Tankyrase inhibitors on the growth of hepatocellular carcinoma (HCC) cell lines and the molecular mechanisms involved. For this purpose, we performed cell proliferation assay by colony-forming ability in seven human HCC cells subjected to XAV-939 and G007-LK Tankyrase inhibitors. Noticeably, the two Tankyrase inhibitors suppressed the HCC cell growth in a dose-dependent manner. Furthermore, we found that Tankyrase inhibitors synergized with MEK and AKT inhibitors to suppress HCC cell proliferation. At the molecular level, Tankyrase inhibitors significantly decreased YAP protein levels, reduced the expression of YAP target genes, and inhibited YAP/TEAD luciferase reporter activity. In addition, Tankyrase inhibitors administration was accompanied by upregulation of Angiomotin-like 1 (AMOTL1) and Angiomotin-like 2 (AMOTL2) proteins, two major negative regulators of YAP. Altogether, the present data indicate that XAV-939 and G007-LK Tankyrase inhibitors could suppress proliferation of hepatocellular carcinoma cells and downregulate YAP/TAZ by stabilizing AMOTL1 and AMOTL2 proteins, thus representing new potential anticancer drugs against hepatocellular carcinoma. |Adaptor Proteins, Signal Transducing/metabolism [MESH] |Angiomotins [MESH] |Antineoplastic Agents/*therapeutic use [MESH] |Apoptosis/drug effects [MESH] |Blotting, Western [MESH] |Carcinoma, Hepatocellular/*drug therapy [MESH] |Carrier Proteins/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |Dose-Response Relationship, Drug [MESH] |Heterocyclic Compounds, 3-Ring/*therapeutic use [MESH] |Humans [MESH] |Liver Neoplasms/*drug therapy [MESH] |Membrane Proteins/metabolism [MESH] |Phosphoproteins/metabolism [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Sulfones/*therapeutic use [MESH] |Tankyrases/*antagonists & inhibitors [MESH] |Transcription Factors [MESH] |Triazoles/*therapeutic use [MESH]Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via(epmc).pdf DeepDyve Pubget Overpricing