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10.1016/j.ccell.2017.04.005 http://scihub22266oqcxt.onion/10.1016/j.ccell.2017.04.005 C5587180!5587180 !28486105     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28486105 &cmd=llinks): Failed to open stream: HTTP request failed! 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CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes |pdf=|usr=}}{{28486105 }} gab.com Text CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=28486105 #FOAvip An oncogenic role for CHD4, a NuRD component, is defined for initiating and supporting tumor suppressor gene (TSG) silencing in human colorectal cancer. CHD4 recruits repressive chromatin proteins to sites of DNA damage repair, including DNA methyltransferases where it imposes de novo DNA methylation. At TSGs, CHD4 retention helps maintain DNA hypermethylation-associated transcriptional silencing. CHD4 is recruited by the excision repair protein OGG1 for oxidative damage to interact with the damage-induced base 8-hydroxydeoxyguanosine (8-OHdG), while ZMYND8 recruits it to double-strand breaks. CHD4 knockdown activates silenced TSGs, revealing their role for blunting colorectal cancer cell proliferation, invasion, and metastases. High CHD4 and 8-OHdG levels plus low expression of TSGs strongly correlates with early disease recurrence and decreased overall survival. Twit Text FOAVip CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=28486105 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28486105 #FOAvip English Wikipedia <ref>{{Cite pmid|28486105 }}</ref> CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes #MMPMID28486105 Xia L ; Huang W ; Bellani M ; Seidman MM ; Wu K ; Fan D ; Nie Y ; Cai Y ; Zhang YW ; Yu LR ; Li H ; Zahnow CA ; Xie W ; Chiu Yen RW ; Rassool FV ; Baylin SB Cancer Cell 2017[May]; 31 (5 ): 653-668.e7 PMID28486105 show ga An oncogenic role for CHD4, a NuRD component, is defined for initiating and supporting tumor suppressor gene (TSG) silencing in human colorectal cancer. CHD4 recruits repressive chromatin proteins to sites of DNA damage repair, including DNA methyltransferases where it imposes de novo DNA methylation. At TSGs, CHD4 retention helps maintain DNA hypermethylation-associated transcriptional silencing. CHD4 is recruited by the excision repair protein OGG1 for oxidative damage to interact with the damage-induced base 8-hydroxydeoxyguanosine (8-OHdG), while ZMYND8 recruits it to double-strand breaks. CHD4 knockdown activates silenced TSGs, revealing their role for blunting colorectal cancer cell proliferation, invasion, and metastases. High CHD4 and 8-OHdG levels plus low expression of TSGs strongly correlates with early disease recurrence and decreased overall survival. |*DNA Methylation [MESH] |*Epigenetic Repression [MESH] |*Gene Expression Regulation, Neoplastic [MESH] |*Gene Silencing [MESH] |*Genes, Tumor Suppressor [MESH] |8-Hydroxy-2'-Deoxyguanosine [MESH] |Animals [MESH] |Autoantigens/*genetics/metabolism [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Clustered Regularly Interspaced Short Palindromic Repeats [MESH] |Colorectal Neoplasms/enzymology/*genetics/pathology/surgery [MESH] |DNA (Cytosine-5-)-Methyltransferases/genetics/metabolism [MESH] |DNA Damage [MESH] |DNA Glycosylases/genetics/metabolism [MESH] |Deoxyguanosine/analogs & derivatives/metabolism [MESH] |Disease-Free Survival [MESH] |Down-Regulation [MESH] |Enhancer of Zeste Homolog 2 Protein/genetics/metabolism [MESH] |HCT116 Cells [MESH] |Histocompatibility Antigens/genetics/metabolism [MESH] |Histone-Lysine N-Methyltransferase/genetics/metabolism [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Mi-2 Nucleosome Remodeling and Deacetylase Complex/*genetics/metabolism [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Neoplasm Metastasis [MESH] |Oxidative Stress [MESH] |Proportional Hazards Models [MESH] |RNA Interference [MESH] |Receptors for Activated C Kinase [MESH] |Receptors, Cell Surface/genetics/metabolism [MESH] |Time Factors [MESH] |Transcription, Genetic [MESH] |Transfection [MESH]CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic (epmc).pdf DeepDyve Pubget Overpricing