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10.1080/15384101.2017.1356508 http://scihub22266oqcxt.onion/10.1080/15384101.2017.1356508 C5587028!5587028!28749195     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Cycle 2017 ; 16 (17): 1601-10 Nephropedia Template TP {{tp|p=28749195|t=2017. Hippo pathway contributes to cisplatin resistant-induced EMT in nasopharyngeal carcinoma cells |pdf=|usr=}}{{28749195}} gab.com Text Hippo pathway contributes to cisplatin resistant-induced EMT in nasopharyngeal carcinoma cells JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=28749195 #FOAvip Nasopharyngeal carcinoma (NPC) is a kind of head-neck malignant tumor derived from the nasopharyngeal epithelium and is mainly prevalent in Southern China and Southeast Asia countries. Cisplatin (DDP) provides the first-line therapeutic administration in NPC patients. However, chemoresistance has been a main barrier and caused bad treatment outcome in NPC therapy. To understand the molecular mechanism of acquired resistance to DDP, multiple methods were performed to examine the morphocytology and molecular changes in DDP-resistant NPC cells. We found that drug resistance cells displayed epithelial-mesenchymal transition (EMT) characteristics. DDP-resistant NPC cells exhibited enhanced migration and invasion potential. Moreover, overexpression of TAZ, one key gene in Hippo pathway, is closely associated with the DDP resistance of NPC cells and its EMT properties. Depletion of TAZ in DDP-resistant cells reversed EMT phenotypes to MET characteristics and restored chemosensitivity of DDP-resistant cells to DDP treatment. These results suggest that inactivation of TAZ could be a promising approach for the treatment of NPC patients. Twit Text FOAVip Hippo pathway contributes to cisplatin resistant-induced EMT in nasopharyngeal carcinoma cells ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=28749195 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28749195 #FOAvip English Wikipedia <ref>{{Cite pmid|28749195}}</ref> Hippo pathway contributes to cisplatin resistant-induced EMT in nasopharyngeal carcinoma cells #MMPMID28749195 Li S; Zhang X; Zhang R; Liang Z; Liao W; Du Z; Gao C; Liu F; Fan Y; Hong H Cell Cycle 2017[]; 16 (17): 1601-10 PMID28749195show ga Nasopharyngeal carcinoma (NPC) is a kind of head-neck malignant tumor derived from the nasopharyngeal epithelium and is mainly prevalent in Southern China and Southeast Asia countries. Cisplatin (DDP) provides the first-line therapeutic administration in NPC patients. However, chemoresistance has been a main barrier and caused bad treatment outcome in NPC therapy. To understand the molecular mechanism of acquired resistance to DDP, multiple methods were performed to examine the morphocytology and molecular changes in DDP-resistant NPC cells. We found that drug resistance cells displayed epithelial-mesenchymal transition (EMT) characteristics. DDP-resistant NPC cells exhibited enhanced migration and invasion potential. Moreover, overexpression of TAZ, one key gene in Hippo pathway, is closely associated with the DDP resistance of NPC cells and its EMT properties. Depletion of TAZ in DDP-resistant cells reversed EMT phenotypes to MET characteristics and restored chemosensitivity of DDP-resistant cells to DDP treatment. These results suggest that inactivation of TAZ could be a promising approach for the treatment of NPC patients. äHippo pathway contributes to cisplatin resistant-induced EMT in nasoph(epmc).pdf DeepDyve Pubget Overpricing