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10.1016/j.jaci.2016.12.989 http://scihub22266oqcxt.onion/10.1016/j.jaci.2016.12.989 C5587023!5587023!28342911     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Allergy+Clin+Immunol 2017 ; 140 (3): 750-758.e15 Nephropedia Template TP {{tp|p=28342911|t=2017. Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis |pdf=|usr=}}{{28342911}} gab.com Text Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28342911 #FOAvip Background: The role of basophils in anaphylaxis is unclear. Objective: We sought to investigate whether basophils have an important role in human anaphylaxis. Methods: In an emergency department study we recruited 31 patients with acute anaphylaxis, predominantly to Hymenoptera venom. We measured expression of basophil activation markers (CD63 and CD203c); the absolute number of circulating basophils; whole-blood FCER1A, carboxypeptidase A3 (CPA3), and L-histidine decarboxylase (HDC) gene expression; and serum markers (CCL2, CCL5, CCL11, IL-3, and thymic stromal lymphopoietin) at 3 time points (ie, during the anaphylactic episode and in convalescent samples 7 and 30 days later). We recruited 134 patients with Hymenoptera allergy and 76 healthy control subjects for comparison. We then investigated whether the changes observed during venom-related anaphylaxis also occur during allergic reactions to food in 22 patients with peanut allergy undergoing double-blind, placebo-controlled food challenge to peanut. Results: The number of circulating basophils was significantly lower during anaphylaxis (median, 3.5 cells/?L) than 7 and 30 days later (17.5 and 24.7 cells/?L, P < .0001) and compared with those in patients with venom allergy and healthy control subjects (21 and 23.4 cells/?L, P < .0001). FCER1A expression during anaphylaxis was also significantly lower than in convalescent samples (P ? .002) and control subjects with venom allergy (P < .0001). CCL2 levels (but not those of other serum markers) were significantly higher during anaphylaxis (median, 658 pg/mL) than in convalescent samples (314 and 311 pg/mL at 7 and 30 days, P < .001). Peanut-induced allergic reactions resulted in a significant decrease in circulating basophil counts compared with those in prechallenge samples (P = .016), a decrease in FCER1A expression (P = .007), and an increase in CCL2 levels (P = .003). Conclusions: Our findings imply an important and specific role for basophils in the pathophysiology of human anaphylaxis. Twit Text FOAVip Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28342911 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28342911 #FOAvip English Wikipedia <ref>{{Cite pmid|28342911}}</ref> Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis #MMPMID28342911 Korosec P; Turner PJ; Silar M; Kopac P; Kosnik M; Gibbs BF; Shamji MH; Custovic A; Rijavec M J Allergy Clin Immunol 2017[Sep]; 140 (3): 750-758.e15 PMID28342911show ga Background: The role of basophils in anaphylaxis is unclear. Objective: We sought to investigate whether basophils have an important role in human anaphylaxis. Methods: In an emergency department study we recruited 31 patients with acute anaphylaxis, predominantly to Hymenoptera venom. We measured expression of basophil activation markers (CD63 and CD203c); the absolute number of circulating basophils; whole-blood FCER1A, carboxypeptidase A3 (CPA3), and L-histidine decarboxylase (HDC) gene expression; and serum markers (CCL2, CCL5, CCL11, IL-3, and thymic stromal lymphopoietin) at 3 time points (ie, during the anaphylactic episode and in convalescent samples 7 and 30 days later). We recruited 134 patients with Hymenoptera allergy and 76 healthy control subjects for comparison. We then investigated whether the changes observed during venom-related anaphylaxis also occur during allergic reactions to food in 22 patients with peanut allergy undergoing double-blind, placebo-controlled food challenge to peanut. Results: The number of circulating basophils was significantly lower during anaphylaxis (median, 3.5 cells/?L) than 7 and 30 days later (17.5 and 24.7 cells/?L, P < .0001) and compared with those in patients with venom allergy and healthy control subjects (21 and 23.4 cells/?L, P < .0001). FCER1A expression during anaphylaxis was also significantly lower than in convalescent samples (P ? .002) and control subjects with venom allergy (P < .0001). CCL2 levels (but not those of other serum markers) were significantly higher during anaphylaxis (median, 658 pg/mL) than in convalescent samples (314 and 311 pg/mL at 7 and 30 days, P < .001). Peanut-induced allergic reactions resulted in a significant decrease in circulating basophil counts compared with those in prechallenge samples (P = .016), a decrease in FCER1A expression (P = .007), and an increase in CCL2 levels (P = .003). Conclusions: Our findings imply an important and specific role for basophils in the pathophysiology of human anaphylaxis. äBasophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis (epmc).pdf DeepDyve Pubget Overpricing