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10.1159/000362667

http://scihub22266oqcxt.onion/10.1159/000362667
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C5586897!5586897!24903210
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suck abstract from ncbi


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pmid24903210      Med+Princ+Pract 2014 ; 23 (4): 331-5
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  • Anti-Carbonic Anhydrase II Antibodies in End-Stage Renal Disease Patients #MMPMID24903210
  • Alver A; Mente?e A; Mente?e Ü; Sümer A; Uçar F; Us Altay D
  • Med Princ Pract 2014[Jul]; 23 (4): 331-5 PMID24903210show ga
  • Objective: The aim of this study was to investigate the presence of anti-carbonic anhydrase (CA II) autoantibodies in patients with end-stage renal disease (ESRD) and relationships between the autoantibody titers and ghrelin, glucose, blood urea nitrogen (BUN) and creatinine. Subjects and Methods: Serum CA II autoantibody titers, malondialdehyde (MDA), BUN, creatinine and ghrelin levels were measured in 45 ESRD patients and 45 healthy subjects. Results: The CA II autoantibody titers in the ESRD group (0.170 ± 0.237) were significantly higher than those in the control group (0.079 ± 0.032; p = 0.035). MDA and ghrelin levels were also significantly higher in the ESRD group (p < 0.001). A weak positive correlation was determined between anti-CA II antibody titers and MDA, and a negative correlation was observed between ghrelin levels and anti-CA II antibody titers (r = 0.287, p = 0.028 and r =b ?0.278, p = 0.032, respectively). Conclusions: In ESRD patients, the results showed the development of an autoimmune response against CA II. This suggests that anti-CA II antibodies could be involved in the pathogenesis of ESRD.
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