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10.1159/000358221 http://scihub22266oqcxt.onion/10.1159/000358221 C5586872!5586872 !24504150     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24504150 &cmd=llinks): Failed to open stream: HTTP request failed! 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Switch-associated protein 70 antibodies in multiple sclerosis: possible association with disease progression |pdf=|usr=}}{{24504150 }} gab.com Text Switch-associated protein 70 antibodies in multiple sclerosis: possible association with disease progression JO: Med Princ Pract http://www.kidney.de/pget.php?&tw=1&pmid=24504150 #FOAvip OBJECTIVE: This study was conducted to identify a biomarker for multiple sclerosis (MS) that can be used as a predictor of relapse and disability. MATERIALS AND METHODS: Sera of 26 consecutive relapsing-remitting MS (RRMS) patients were screened for switch-associated protein 70 (SWAP-70) antibody, which was previously identified by protein macroarray. The serum levels of several cytokines, chemokines and soluble adhesion molecules related to MS attacks were measured by enzyme-linked immunosorbent assay (ELISA). A possible correlation was sought among levels of SWAP-70 antibody, measured humoral factors and disability scores. RESULTS: ELISA studies showed high-titre SWAP-70 antibodies in 16 (61.5%) RRMS sera obtained during the attack period and 9 (34.6%) sera obtained during remission. There was a significant inverse correlation between SWAP-70 antibody levels and expanded disability status scale scores, CXCL10, soluble VCAM-1, CXCL13 and soluble VLA-4 levels. CONCLUSION: Our results showed that SWAP-70 antibodies could potentially be utilized as relapse and prognostic biomarkers in MS. Whether or not SWAP-70 antibodies have any effect on disease mechanisms requires further investigation. Twit Text FOAVip Switch-associated protein 70 antibodies in multiple sclerosis: possible association with disease progression ????Med Princ Pract http://www.kidney.de/pget.php?&tw=1&pmid=24504150 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24504150 #FOAvip English Wikipedia <ref>{{Cite pmid|24504150 }}</ref> Switch-associated protein 70 antibodies in multiple sclerosis: possible association with disease progression #MMPMID24504150 Türko?lu R ; Gencer M ; Ekmekçi D ; Ulusoy C ; Erda? E ; Sehito?lu E ; Cavu? F ; Haytural H ; Küçükerden M ; Yalç?nkaya N ; Turan S ; Akba?-Demir D ; Coban A ; Vural B ; Tüzün E Med Princ Pract 2014[]; 23 (3 ): 239-45 PMID24504150 show ga OBJECTIVE: This study was conducted to identify a biomarker for multiple sclerosis (MS) that can be used as a predictor of relapse and disability. MATERIALS AND METHODS: Sera of 26 consecutive relapsing-remitting MS (RRMS) patients were screened for switch-associated protein 70 (SWAP-70) antibody, which was previously identified by protein macroarray. The serum levels of several cytokines, chemokines and soluble adhesion molecules related to MS attacks were measured by enzyme-linked immunosorbent assay (ELISA). A possible correlation was sought among levels of SWAP-70 antibody, measured humoral factors and disability scores. RESULTS: ELISA studies showed high-titre SWAP-70 antibodies in 16 (61.5%) RRMS sera obtained during the attack period and 9 (34.6%) sera obtained during remission. There was a significant inverse correlation between SWAP-70 antibody levels and expanded disability status scale scores, CXCL10, soluble VCAM-1, CXCL13 and soluble VLA-4 levels. CONCLUSION: Our results showed that SWAP-70 antibodies could potentially be utilized as relapse and prognostic biomarkers in MS. Whether or not SWAP-70 antibodies have any effect on disease mechanisms requires further investigation. |Adult [MESH] |Biomarkers [MESH] |Cytokines/immunology [MESH] |DNA-Binding Proteins/*immunology [MESH] |Disease Progression [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Female [MESH] |Guanine Nucleotide Exchange Factors/*immunology [MESH] |Humans [MESH] |Immunoglobulin G/immunology [MESH] |Male [MESH] |Middle Aged [MESH] |Minor Histocompatibility Antigens [MESH] |Multiple Sclerosis, Relapsing-Remitting/*immunology [MESH]Switch-associated protein 70 antibodies in multiple sclerosis: possibl(epmc).pdf DeepDyve Pubget Overpricing