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2013 ; 22
(3
): 209-19
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Synthetic biology and personalized medicine
#MMPMID22907209
Jain KK
Med Princ Pract
2013[]; 22
(3
): 209-19
PMID22907209
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Synthetic biology, application of synthetic chemistry to biology, is a broad term
that covers the engineering of biological systems with structures and functions
not found in nature to process information, manipulate chemicals, produce energy,
maintain cell environment and enhance human health. Synthetic biology devices
contribute not only to improve our understanding of disease mechanisms, but also
provide novel diagnostic tools. Methods based on synthetic biology enable the
design of novel strategies for the treatment of cancer, immune diseases metabolic
disorders and infectious diseases as well as the production of cheap drugs. The
potential of synthetic genome, using an expanded genetic code that is designed
for specific drug synthesis as well as delivery and activation of the drug in
vivo by a pathological signal, was already pointed out during a lecture delivered
at Kuwait University in 2005. Of two approaches to synthetic biology, top-down
and bottom-up, the latter is more relevant to the development of personalized
medicines as it provides more flexibility in constructing a partially synthetic
cell from basic building blocks for a desired task.
|Artificial Cells
[MESH]
|Biosensing Techniques
[MESH]
|Cell- and Tissue-Based Therapy/ethics/*methods
[MESH]
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