Protein Structure Annotation Resources #MMPMID25502191
Gabanyi MJ; Berman HM
Methods Mol Biol 2015[]; 1261 (ä): 3-20 PMID25502191show ga
A key reason three-dimensional (3?D) protein structures are annotated with supporting or derived information is to understand the molecular basis of protein function. To this end, protein structure annotation databases curate key facts and observations, based on community-accepted standards, about the ~100,000 3-D experimental protein structures that enable further insight into the structure-function relationship. This review will introduce the primary structure repositories, databases, and value-added structural annotation databases, as well as the range of annotations they provide. The different levels of annotation data (primary vs. derived vs. inferred) will also be described and how they should all be considered accordingly.