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10.1016/j.celrep.2017.06.082 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.06.082 C5586494!5586494!28746874     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2017 ; 20 (4): 895-908 Nephropedia Template TP {{tp|p=28746874|t=2017. Glycolytic Enzymes Coalesce in G bodies Under Hypoxic Stress |pdf=|usr=}}{{28746874}} gab.com Text Glycolytic Enzymes Coalesce in G bodies Under Hypoxic Stress JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28746874 #FOAvip Glycolysis is upregulated under conditions such as hypoxia and high energy demand to promote cell proliferation, although the mechanism remains poorly understood. We find that hypoxia in Saccharomyces cerevisiae induces concentration of glycolytic enzymes, including the Pfk2p subunit of the rate-limiting phosphofructokinase, into a single, non-membrane-bound granule termed the ?glycolytic body? or ?G body?. A yeast kinome screen identifies the yeast ortholog of AMP-activated protein kinase, Snf1p, as necessary for G body formation. Many G body components identified by proteomics are required for G body integrity. Cells incapable of forming G bodies in hypoxia display abnormal cell division and produce inviable daughter cells. Conversely, cells with G bodies show increased glucose consumption and decreased levels of glycolytic intermediates. Importantly, G bodies form in human hepatocarcinoma cells in hypoxia. Together, our results suggest that G body formation is a conserved, adaptive response to increase glycolytic output during hypoxia or tumorigenesis. Twit Text FOAVip Glycolytic Enzymes Coalesce in G bodies Under Hypoxic Stress ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28746874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28746874 #FOAvip English Wikipedia <ref>{{Cite pmid|28746874}}</ref> Glycolytic Enzymes Coalesce in G bodies Under Hypoxic Stress #MMPMID28746874 Jin M; Fuller GG; Han T; Yao Y; Alessi AF; Freeberg MA; Roach N; Moresco JJ; Karnovsky A; Baba M; Yates JR; Gitler AD; Inoki K; Klionsky DJ; Kim JK Cell Rep 2017[Jul]; 20 (4): 895-908 PMID28746874show ga Glycolysis is upregulated under conditions such as hypoxia and high energy demand to promote cell proliferation, although the mechanism remains poorly understood. We find that hypoxia in Saccharomyces cerevisiae induces concentration of glycolytic enzymes, including the Pfk2p subunit of the rate-limiting phosphofructokinase, into a single, non-membrane-bound granule termed the ?glycolytic body? or ?G body?. A yeast kinome screen identifies the yeast ortholog of AMP-activated protein kinase, Snf1p, as necessary for G body formation. Many G body components identified by proteomics are required for G body integrity. Cells incapable of forming G bodies in hypoxia display abnormal cell division and produce inviable daughter cells. Conversely, cells with G bodies show increased glucose consumption and decreased levels of glycolytic intermediates. Importantly, G bodies form in human hepatocarcinoma cells in hypoxia. Together, our results suggest that G body formation is a conserved, adaptive response to increase glycolytic output during hypoxia or tumorigenesis. äGlycolytic Enzymes Coalesce in G bodies Under Hypoxic Stress (epmc).pdf DeepDyve Pubget Overpricing