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10.1161/JAHA.117.006380 http://scihub22266oqcxt.onion/10.1161/JAHA.117.006380 C5586466!5586466 !28835362     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28835362 &cmd=llinks): Failed to open stream: HTTP request failed! 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Association Between Acidosis Soon After Reperfusion and Contrast-Induced Nephropathy in Patients With a First-Time ST-Segment Elevation Myocardial Infarction |pdf=|usr=}}{{28835362 }} gab.com Text Association Between Acidosis Soon After Reperfusion and Contrast-Induced Nephropathy in Patients With a First-Time ST-Segment Elevation Myocardial Infarction JO: J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=28835362 #FOAvip BACKGROUND: Contrast-induced nephropathy (CIN) is associated with poor outcomes in patients with acute myocardial infarction. However, the predictors of CIN have yet to be fully elucidated. METHODS AND RESULTS: The study included 273 consecutive patients with a first-time ST-segment elevation myocardial infarction who underwent reperfusion within 12 hours of symptom onset. The exclusion criteria were hemodialysis, mechanical ventilation, or previous coronary artery bypass grafting. All patients underwent arterial blood gas analysis soon after reperfusion. CIN was defined as an increase of 0.5 mg/dL in serum creatinine or a 25% increase from baseline between 48 and 72 hours after contrast medium exposure. Acidosis was defined as an arterial blood pH <7.35. CIN was observed in 35 patients (12.8%). Multivariable logistic regression analysis with forward stepwise algorithm revealed a significant association between CIN and the following: reperfusion time, the prevalence of hypertension, peak creatine kinase-MB, high-sensitivity C-reactive protein on admission, and the incidence of acidosis (P<0.05). Multivariable logistic regression analysis revealed that the incidence of acidosis was associated with CIN when adjusted for age, male sex, body mass index, amount of contrast medium used, estimated glomerular filtration rate on admission, glucose level on admission, high-sensitivity C-reactive protein on admission, and left ventricular ejection fraction (P<0.05). Moreover, the incidence of acidosis was associated with CIN when adjusted for the Mehran CIN risk score (odds ratio: 2.229, P=0.049). CONCLUSIONS: The incidence of acidosis soon after reperfusion was associated with CIN in patients with a first-time ST-segment elevation myocardial infarction. Twit Text FOAVip Association Between Acidosis Soon After Reperfusion and Contrast-Induced Nephropathy in Patients With a First-Time ST-Segment Elevation Myocardial Infarction ????J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=28835362 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28835362 #FOAvip English Wikipedia <ref>{{Cite pmid|28835362 }}</ref> Association Between Acidosis Soon After Reperfusion and Contrast-Induced Nephropathy in Patients With a First-Time ST-Segment Elevation Myocardial Infarction #MMPMID28835362 Gohbara M ; Hayakawa A ; Akazawa Y ; Furihata S ; Kondo A ; Fukushima Y ; Tomari S ; Endo T ; Kimura K ; Tamura K J Am Heart Assoc 2017[Aug]; 6 (8 ): ä PMID28835362 show ga BACKGROUND: Contrast-induced nephropathy (CIN) is associated with poor outcomes in patients with acute myocardial infarction. However, the predictors of CIN have yet to be fully elucidated. METHODS AND RESULTS: The study included 273 consecutive patients with a first-time ST-segment elevation myocardial infarction who underwent reperfusion within 12 hours of symptom onset. The exclusion criteria were hemodialysis, mechanical ventilation, or previous coronary artery bypass grafting. All patients underwent arterial blood gas analysis soon after reperfusion. CIN was defined as an increase of 0.5 mg/dL in serum creatinine or a 25% increase from baseline between 48 and 72 hours after contrast medium exposure. Acidosis was defined as an arterial blood pH <7.35. CIN was observed in 35 patients (12.8%). Multivariable logistic regression analysis with forward stepwise algorithm revealed a significant association between CIN and the following: reperfusion time, the prevalence of hypertension, peak creatine kinase-MB, high-sensitivity C-reactive protein on admission, and the incidence of acidosis (P<0.05). Multivariable logistic regression analysis revealed that the incidence of acidosis was associated with CIN when adjusted for age, male sex, body mass index, amount of contrast medium used, estimated glomerular filtration rate on admission, glucose level on admission, high-sensitivity C-reactive protein on admission, and left ventricular ejection fraction (P<0.05). Moreover, the incidence of acidosis was associated with CIN when adjusted for the Mehran CIN risk score (odds ratio: 2.229, P=0.049). CONCLUSIONS: The incidence of acidosis soon after reperfusion was associated with CIN in patients with a first-time ST-segment elevation myocardial infarction. |Acid-Base Equilibrium [MESH] |Acidosis/blood/*epidemiology/mortality/physiopathology [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Biomarkers/blood [MESH] |Blood Gas Analysis [MESH] |Chi-Square Distribution [MESH] |Contrast Media/*adverse effects [MESH] |Creatinine/blood [MESH] |Female [MESH] |Hospital Mortality [MESH] |Humans [MESH] |Incidence [MESH] |Japan/epidemiology [MESH] |Kidney Diseases/blood/chemically induced/*epidemiology/mortality [MESH] |Logistic Models [MESH] |Male [MESH] |Middle Aged [MESH] |Multivariate Analysis [MESH] |Myocardial Reperfusion/*adverse effects/mortality [MESH] |Odds Ratio [MESH] |Prevalence [MESH] |Retrospective Studies [MESH] |Risk Assessment [MESH] |Risk Factors [MESH] |ST Elevation Myocardial Infarction/diagnostic imaging/mortality/*therapy [MESH] |Time Factors [MESH]Association Between Acidosis Soon After Reperfusion and Contrast-Induc(epmc).pdf DeepDyve Pubget Overpricing