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10.1161/JAHA.117.006196 http://scihub22266oqcxt.onion/10.1161/JAHA.117.006196 C5586457!5586457 !28862930     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28862930 &cmd=llinks): Failed to open stream: HTTP request failed! 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Blood Pressure Response to Main Renal Artery and Combined Main Renal Artery Plus Branch Renal Denervation in Patients With Resistant Hypertension |pdf=|usr=}}{{28862930 }} gab.com Text Blood Pressure Response to Main Renal Artery and Combined Main Renal Artery Plus Branch Renal Denervation in Patients With Resistant Hypertension JO: J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=28862930 #FOAvip BACKGROUND: Single-electrode ablation of the main renal artery for renal sympathetic denervation showed mixed blood pressure (BP)-lowering effects. Further improvement of the technique seems crucial to optimize effectiveness of the procedure. Because sympathetic nerve fibers are closer to the lumen in the distal part of the renal artery, treatment of the distal main artery and its branches has been shown to reduce variability in treatment effects in preclinical studies and a recent randomized trial. Whether this optimized technique improves clinical outcomes remains uncertain. We report a 2-center experience of main renal artery and combined main renal artery plus branches renal denervation in patients with resistant hypertension using a multielectrode catheter. METHODS AND RESULTS: Twenty-five patients with therapy-resistant hypertension underwent renal sympathetic denervation with combined main renal artery and renal branch ablation and were compared to matched controls undergoing an ablation of the main renal artery only. BP change was assessed by ambulatory measurement at baseline and after 3 months. At baseline, BP was balanced between the groups. After 3 months, BP changed significantly in the combined ablation group (systolic/diastolic 24-hour mean and daytime mean BP -8.5±9.8/-7.0±10.7 and -9.4±9.8/-7.1±13.5 mm Hg, P<0.001/0.003 and <0.001/0.016, respectively), but not in patients with main artery treatment (-3.5±11.1/-2.0±7.6 and -2.8±10.9/-1.8±7.7 mm Hg, P=0.19/0.20 and 0.19/0.24, respectively). Systolic daytime BP was significantly more reduced in patients with combined ablation than in patients with main artery ablation (P=0.033). CONCLUSIONS: Combined ablation of the main renal artery and branches appears to improve BP-lowering efficacy and should be further investigated. Twit Text FOAVip Blood Pressure Response to Main Renal Artery and Combined Main Renal Artery Plus Branch Renal Denervation in Patients With Resistant Hypertension ????J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=28862930 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28862930 #FOAvip English Wikipedia <ref>{{Cite pmid|28862930 }}</ref> Blood Pressure Response to Main Renal Artery and Combined Main Renal Artery Plus Branch Renal Denervation in Patients With Resistant Hypertension #MMPMID28862930 Fengler K ; Ewen S ; Höllriegel R ; Rommel KP ; Kulenthiran S ; Lauder L ; Cremers B ; Schuler G ; Linke A ; Böhm M ; Mahfoud F ; Lurz P J Am Heart Assoc 2017[Aug]; 6 (8 ): ä PMID28862930 show ga BACKGROUND: Single-electrode ablation of the main renal artery for renal sympathetic denervation showed mixed blood pressure (BP)-lowering effects. Further improvement of the technique seems crucial to optimize effectiveness of the procedure. Because sympathetic nerve fibers are closer to the lumen in the distal part of the renal artery, treatment of the distal main artery and its branches has been shown to reduce variability in treatment effects in preclinical studies and a recent randomized trial. Whether this optimized technique improves clinical outcomes remains uncertain. We report a 2-center experience of main renal artery and combined main renal artery plus branches renal denervation in patients with resistant hypertension using a multielectrode catheter. METHODS AND RESULTS: Twenty-five patients with therapy-resistant hypertension underwent renal sympathetic denervation with combined main renal artery and renal branch ablation and were compared to matched controls undergoing an ablation of the main renal artery only. BP change was assessed by ambulatory measurement at baseline and after 3 months. At baseline, BP was balanced between the groups. After 3 months, BP changed significantly in the combined ablation group (systolic/diastolic 24-hour mean and daytime mean BP -8.5±9.8/-7.0±10.7 and -9.4±9.8/-7.1±13.5 mm Hg, P<0.001/0.003 and <0.001/0.016, respectively), but not in patients with main artery treatment (-3.5±11.1/-2.0±7.6 and -2.8±10.9/-1.8±7.7 mm Hg, P=0.19/0.20 and 0.19/0.24, respectively). Systolic daytime BP was significantly more reduced in patients with combined ablation than in patients with main artery ablation (P=0.033). CONCLUSIONS: Combined ablation of the main renal artery and branches appears to improve BP-lowering efficacy and should be further investigated. |*Blood Pressure/drug effects [MESH] |Aged [MESH] |Angiography [MESH] |Antihypertensive Agents/therapeutic use [MESH] |Case-Control Studies [MESH] |Catheter Ablation/adverse effects/instrumentation/*methods [MESH] |Drug Resistance [MESH] |Electrodes [MESH] |Equipment Design [MESH] |Female [MESH] |Humans [MESH] |Hypertension/diagnosis/physiopathology/*surgery [MESH] |Kidney/*blood supply [MESH] |Male [MESH] |Middle Aged [MESH] |Prospective Studies [MESH] |Renal Artery/diagnostic imaging/*innervation [MESH] |Sympathectomy/adverse effects/instrumentation/*methods [MESH] |Time Factors [MESH] |Treatment Outcome [MESH]Blood Pressure Response to Main Renal Artery and Combined Main Renal A(epmc).pdf DeepDyve Pubget Overpricing