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10.1161/JAHA.117.006345 http://scihub22266oqcxt.onion/10.1161/JAHA.117.006345 C5586322!5586322!28673898     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Heart+Assoc 2017 ; 6 (7): ä Nephropedia Template TP {{tp|p=28673898|t=2017. Platelet?Derived Factor V Is a Critical Mediator of Arterial Thrombosis |pdf=|usr=}}{{28673898}} gab.com Text Platelet Derived Factor V Is a Critical Mediator of Arterial Thrombosis JO: J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=28673898 #FOAvip Background: Coagulation factor V (FV) plays a key role in hemostasis, is present in plasma and platelets, and has both pro? and anticoagulant properties; however, the contribution of platelet?derived FV to arterial thrombosis remains undetermined. Methods and Results: Using transgenic mice with various levels of FV gene expression that was restricted to the plasma or platelets, the roles of platelet FV were evaluated in the regulation of arterial thrombosis and platelet activation. Mice with higher levels of platelet FV exhibited faster thrombotic occlusion of the carotid artery after injury compared with mice with lower platelet FV levels. Infusion of platelets with higher levels of FV into transgenic mice with undetectable levels of platelet FV reduced the time to carotid artery occlusion. In contrast, infusion of purified recombinant plasma FV into mice with undetectable platelet FV levels failed to reduce the carotid occlusion times following injury. Evaluation of isolated platelets revealed that platelet?derived FV was critical for the regulation of platelet activation. These effects were associated with an increased level of expression of P?selectin and increased cGMP in platelets. Conclusions: We established that platelet?derived FV is a critical mediator of arterial thrombosis that involves platelet activation. Twit Text FOAVip Platelet Derived Factor V Is a Critical Mediator of Arterial Thrombosis ????J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=28673898 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28673898 #FOAvip English Wikipedia <ref>{{Cite pmid|28673898}}</ref> Platelet?Derived Factor V Is a Critical Mediator of Arterial Thrombosis #MMPMID28673898 Ren M; Li R; Chen N; Pang N; Li Y; Deng X; Wang L; Luo M; Liu Y; Hao H; Liu Y; Sun H; Wu J J Am Heart Assoc 2017[Jul]; 6 (7): ä PMID28673898show ga Background: Coagulation factor V (FV) plays a key role in hemostasis, is present in plasma and platelets, and has both pro? and anticoagulant properties; however, the contribution of platelet?derived FV to arterial thrombosis remains undetermined. Methods and Results: Using transgenic mice with various levels of FV gene expression that was restricted to the plasma or platelets, the roles of platelet FV were evaluated in the regulation of arterial thrombosis and platelet activation. Mice with higher levels of platelet FV exhibited faster thrombotic occlusion of the carotid artery after injury compared with mice with lower platelet FV levels. Infusion of platelets with higher levels of FV into transgenic mice with undetectable levels of platelet FV reduced the time to carotid artery occlusion. In contrast, infusion of purified recombinant plasma FV into mice with undetectable platelet FV levels failed to reduce the carotid occlusion times following injury. Evaluation of isolated platelets revealed that platelet?derived FV was critical for the regulation of platelet activation. These effects were associated with an increased level of expression of P?selectin and increased cGMP in platelets. Conclusions: We established that platelet?derived FV is a critical mediator of arterial thrombosis that involves platelet activation. äPlatelet?Derived Factor V Is a Critical Mediator of Arterial Thrombosi(epmc).pdf DeepDyve Pubget Overpricing