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10.1161/JAHA.117.005685 http://scihub22266oqcxt.onion/10.1161/JAHA.117.005685 C5586292!5586292!28684642     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Heart+Assoc 2017 ; 6 (7): ä Nephropedia Template TP {{tp|p=28684642|t=2017. Association of Proteinuria and Incident Atrial Fibrillation in Patients With Intact and Reduced Kidney Function |pdf=|usr=}}{{28684642}} gab.com Text Association of Proteinuria and Incident Atrial Fibrillation in Patients With Intact and Reduced Kidney Function JO: J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=28684642 #FOAvip Background: Early evidence suggests proteinuria is independently associated with incident atrial fibrillation (AF). We sought to investigate whether the association of proteinuria with incident AF is altered by kidney function. Methods and Results: Retrospective cohort study using administrative healthcare databases in Ontario, Canada (2002?2015). A total of 736 666 patients aged ?40 years not receiving dialysis and with no previous history of AF were included. Proteinuria was defined using the urine albumin?to?creatinine ratio (ACR) and kidney function by the estimated glomerular filtration rate (eGFR). The primary outcome was time to AF. Cox proportional models were used to determine the hazard ratio for AF censored for death, dialysis, kidney transplant, or end of follow?up. Fine and Grey models were used to determine the subdistribution hazard ratio for AF, with death as a competing event. Median follow?up was 6 years and 44 809 patients developed AF. In adjusted models, ACR and eGFR were associated with AF (P<0.0001). The association of proteinuria with AF differed based on kidney function (ACR × eGFR interaction, P<0.0001). Overt proteinuria (ACR, 120 mg/mmol) was associated with greater AF risk in patients with intact (eGFR, 120) versus reduced (eGFR, 30) kidney function (adjusted hazard ratios, 4.5 [95% CI, 4.0?5.1] and 2.6 [95% CI, 2.4?2.8], respectively; referent ACR 0 and eGFR 120). Results were similar in competing risk analyses. Conclusions: Proteinuria increases the risk of incident AF markedly in patients with intact kidney function compared with those with decreased kidney function. Screening and preventative strategies should consider proteinuria as an independent risk factor for AF. Twit Text FOAVip Association of Proteinuria and Incident Atrial Fibrillation in Patients With Intact and Reduced Kidney Function ????J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=28684642 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28684642 #FOAvip English Wikipedia <ref>{{Cite pmid|28684642}}</ref> Association of Proteinuria and Incident Atrial Fibrillation in Patients With Intact and Reduced Kidney Function #MMPMID28684642 Molnar AO; Eddeen AB; Ducharme R; Garg AX; Harel Z; McCallum MK; Perl J; Wald R; Zimmerman D; Sood MM J Am Heart Assoc 2017[Jul]; 6 (7): ä PMID28684642show ga Background: Early evidence suggests proteinuria is independently associated with incident atrial fibrillation (AF). We sought to investigate whether the association of proteinuria with incident AF is altered by kidney function. Methods and Results: Retrospective cohort study using administrative healthcare databases in Ontario, Canada (2002?2015). A total of 736 666 patients aged ?40 years not receiving dialysis and with no previous history of AF were included. Proteinuria was defined using the urine albumin?to?creatinine ratio (ACR) and kidney function by the estimated glomerular filtration rate (eGFR). The primary outcome was time to AF. Cox proportional models were used to determine the hazard ratio for AF censored for death, dialysis, kidney transplant, or end of follow?up. Fine and Grey models were used to determine the subdistribution hazard ratio for AF, with death as a competing event. Median follow?up was 6 years and 44 809 patients developed AF. In adjusted models, ACR and eGFR were associated with AF (P<0.0001). The association of proteinuria with AF differed based on kidney function (ACR × eGFR interaction, P<0.0001). Overt proteinuria (ACR, 120 mg/mmol) was associated with greater AF risk in patients with intact (eGFR, 120) versus reduced (eGFR, 30) kidney function (adjusted hazard ratios, 4.5 [95% CI, 4.0?5.1] and 2.6 [95% CI, 2.4?2.8], respectively; referent ACR 0 and eGFR 120). Results were similar in competing risk analyses. Conclusions: Proteinuria increases the risk of incident AF markedly in patients with intact kidney function compared with those with decreased kidney function. Screening and preventative strategies should consider proteinuria as an independent risk factor for AF. äAssociation of Proteinuria and Incident Atrial Fibrillation in Patient(epmc).pdf DeepDyve Pubget Overpricing