Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28874122
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28874122
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 BMC+Nephrol
2017 ; 18
(1
): 285
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Doxycycline treatment in dialysis related amyloidosis: discrepancy between
antalgic effect and inflammation, studied with FDG-positron emission tomography:
a case report
#MMPMID28874122
Piccoli GB
; Hachemi M
; Molfino I
; Coindre JP
; Boursot C
BMC Nephrol
2017[Sep]; 18
(1
): 285
PMID28874122
show ga
BACKGROUND: No effective treatment is currently available and dialysis related
amyloidosis continues to be invalidating in long-term dialysis patients. A recent
case series reported reduction of osteoarticular pain on doxycycline treatment,
extending the indications of this drug, used in other uncommon forms of
amyloidosis, to dialysis patients. Explanations of the antalgic effect were the
anti-inflammatory properties and anti-coiling effects of tetracycline. CASE
PRESENTATION: Our report regards a 54-year-old woman, who was never transplanted
and has been on hemodialysis and hemodiafiltration for overall 37 years, due to
renal hypoplasia. In spite of high efficiency hemodiafiltration, she complained
of increasing, invalidating osteoarticular pain; history and imaging suggested
beta-2 microglobulin amyloid. Positron emission tomography (PET scan) identified
metabolically active lesions in the involved settings. Low-dose doxycycline
(100 mg/day) was started, leading to a considerable decrease in pain (over
6 months, from 7 to 8 to 4-5 on a 0-10 scale). At 6 months, a PET scan showed
unmodified or increased uptake in the involved settings. CONCLUSIONS: In summary,
the previously described antalgic effect of doxycycline in dialysis related
amyloidosis is confirmed in our case, the first studied using PET scan. The
pattern at PET can suggests that the antalgic effect is independent from
inflammation and points to other factors, such as interaction with fibril
geometry or with bone structure.