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10.1186/s40560-017-0250-z http://scihub22266oqcxt.onion/10.1186/s40560-017-0250-z C5585957!5585957!28904799     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Intensive+Care 2017 ; 5 (ä): ä Nephropedia Template TP {{tp|p=28904799|t=2017. Clinical significance of measuring plasminogen activator inhibitor-1 in sepsis |pdf=|usr=}}{{28904799}} gab.com Text Clinical significance of measuring plasminogen activator inhibitor-1 in sepsis JO: J Intensive Care http://www.kidney.de/pget.php?&tw=1&pmid=28904799 #FOAvip Background: Disseminated thrombotic process in the microcirculation is considered to be an important cause of multiple organ dysfunction in sepsis. The fundamental purpose of this prothrombotic change was believed to be in the host defense against microbial dissemination. In that process, antifibrinolytic property plays an important role. Main body: For the understanding of pathophysiology of sepsis, it is quite useful to grasp the alterations in coagulation/fibrinolytic parameters, i.e., plasminogen activator and plasminogen activator inhibitor-1. They play crucial roles in the development of clot formation and disseminated intravascular coagulation that leads to fatal organ dysfunction. Basically, fibrinolysis is a simple system compared to the complex coagulation cascade. Plasmin is the only factor that regulates fibrinolysis, and this enzyme is modulated by several factors including plasminogen activators and plasminogen activator inhibitor-1. However, recent studies have elucidated the complex regulation of the production, activation, and inactivation of these fibrinolytic factors. Conclusion: The dynamic change of the fibrinolytic system plays a crucial role in the pathophysiology of sepsis. In this commentary, we introduce the recent advances of the research regarding fibrinolytic system. Twit Text FOAVip Clinical significance of measuring plasminogen activator inhibitor-1 in sepsis ????J Intensive Care http://www.kidney.de/pget.php?&tw=1&pmid=28904799 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28904799 #FOAvip English Wikipedia <ref>{{Cite pmid|28904799}}</ref> Clinical significance of measuring plasminogen activator inhibitor-1 in sepsis #MMPMID28904799 Iba T; Thachil J J Intensive Care 2017[]; 5 (ä): ä PMID28904799show ga Background: Disseminated thrombotic process in the microcirculation is considered to be an important cause of multiple organ dysfunction in sepsis. The fundamental purpose of this prothrombotic change was believed to be in the host defense against microbial dissemination. In that process, antifibrinolytic property plays an important role. Main body: For the understanding of pathophysiology of sepsis, it is quite useful to grasp the alterations in coagulation/fibrinolytic parameters, i.e., plasminogen activator and plasminogen activator inhibitor-1. They play crucial roles in the development of clot formation and disseminated intravascular coagulation that leads to fatal organ dysfunction. Basically, fibrinolysis is a simple system compared to the complex coagulation cascade. Plasmin is the only factor that regulates fibrinolysis, and this enzyme is modulated by several factors including plasminogen activators and plasminogen activator inhibitor-1. However, recent studies have elucidated the complex regulation of the production, activation, and inactivation of these fibrinolytic factors. Conclusion: The dynamic change of the fibrinolytic system plays a crucial role in the pathophysiology of sepsis. In this commentary, we introduce the recent advances of the research regarding fibrinolytic system. äClinical significance of measuring plasminogen activator inhibitor-1 i(epmc).pdf DeepDyve Pubget Overpricing