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10.1038/s41598-017-11030-5 http://scihub22266oqcxt.onion/10.1038/s41598-017-11030-5 C5585315!5585315 !28874749     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28874749 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 10578 Nephropedia Template TP {{tp|p=28874749 |t=2017. Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol |pdf=|usr=}}{{28874749 }} gab.com Text Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28874749 #FOAvip Mitochondrial dysfunction is associated with numerous acute and chronic degenerative diseases. The beta-2 adrenergic receptor (?(2)AR) agonist formoterol induces mitochondrial biogenesis (MB), but other ?(2)AR agonists, such as clenbuterol, do not. We sought to identify the MB signaling pathway of formoterol and the differences in signaling between these two ligands that result in the differential induction of MB. While formoterol and clenbuterol increased cAMP, only formoterol increased the phosphorylation of Akt and its downstream target eNOS. The increase in Akt phosphorylation was G??- and PI3K-dependent, and the increase in eNOS phosphorylation was G??- and Akt-dependent. Only formoterol increased cGMP. Formoterol induced MB as measured by increases in uncoupled cellular respiration and PGC-1? and NDUFS1 mRNA expression and was blocked by inhibitors of G??, Akt, NOS, and soluble guanylate cyclase. To identify distinct receptor-ligand interactions leading to these differences in signaling, we docked formoterol and clenbuterol to six structures of the ?(2)AR. Compared to clenbuterol, the methoxyphenyl group of formoterol interacted more frequently with V114 and F193, while its formamide group interacted more frequently with C191. These data indicate that the unique structural features of formoterol allow it to interact with the ?(2)AR to activate the G??-Akt-eNOS-sGC pathway to induce MB. Twit Text FOAVip Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28874749 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28874749 #FOAvip English Wikipedia <ref>{{Cite pmid|28874749 }}</ref> Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol #MMPMID28874749 Cameron RB ; Peterson YK ; Beeson CC ; Schnellmann RG Sci Rep 2017[Sep]; 7 (1 ): 10578 PMID28874749 show ga Mitochondrial dysfunction is associated with numerous acute and chronic degenerative diseases. The beta-2 adrenergic receptor (?(2)AR) agonist formoterol induces mitochondrial biogenesis (MB), but other ?(2)AR agonists, such as clenbuterol, do not. We sought to identify the MB signaling pathway of formoterol and the differences in signaling between these two ligands that result in the differential induction of MB. While formoterol and clenbuterol increased cAMP, only formoterol increased the phosphorylation of Akt and its downstream target eNOS. The increase in Akt phosphorylation was G??- and PI3K-dependent, and the increase in eNOS phosphorylation was G??- and Akt-dependent. Only formoterol increased cGMP. Formoterol induced MB as measured by increases in uncoupled cellular respiration and PGC-1? and NDUFS1 mRNA expression and was blocked by inhibitors of G??, Akt, NOS, and soluble guanylate cyclase. To identify distinct receptor-ligand interactions leading to these differences in signaling, we docked formoterol and clenbuterol to six structures of the ?(2)AR. Compared to clenbuterol, the methoxyphenyl group of formoterol interacted more frequently with V114 and F193, while its formamide group interacted more frequently with C191. These data indicate that the unique structural features of formoterol allow it to interact with the ?(2)AR to activate the G??-Akt-eNOS-sGC pathway to induce MB. |*Organelle Biogenesis [MESH] |Animals [MESH] |Cell Respiration/drug effects [MESH] |Clenbuterol/*chemistry/*pharmacology [MESH] |Cyclic GMP/metabolism [MESH] |Epithelial Cells/drug effects/metabolism [MESH] |Formoterol Fumarate/*chemistry/*pharmacology [MESH] |Kidney Tubules, Proximal/cytology [MESH] |Mitochondria/*drug effects/*metabolism [MESH] |Models, Molecular [MESH] |Molecular Conformation [MESH] |Oxygen Consumption [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Phosphorylation [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH]Structural and pharmacological basis for the induction of mitochondria(epmc).pdf DeepDyve Pubget Overpricing