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10.1038/s41467-017-00482-y http://scihub22266oqcxt.onion/10.1038/s41467-017-00482-y C5585248!5585248 !28874662     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28874662 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 444 Nephropedia Template TP {{tp|p=28874662 |t=2017. Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography |pdf=|usr=}}{{28874662 }} gab.com Text Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28874662 #FOAvip Many pathophysiological processes are associated with proliferation, migration or death of distinct cell populations. Monitoring specific cell types and their progeny in a non-invasive, longitudinal and quantitative manner is still challenging. Here we show a novel cell-tracking system that combines Cre/lox-assisted cell fate mapping with a thymidine kinase (sr39tk) reporter gene for cell detection by positron emission tomography (PET). We generate Rosa26-mT/sr39tk PET reporter mice and induce sr39tk expression in platelets, T lymphocytes or cardiomyocytes. As proof of concept, we demonstrate that our mouse model permits longitudinal PET imaging and quantification of T-cell homing during inflammation and cardiomyocyte viability after myocardial infarction. Moreover, Rosa26-mT/sr39tk mice are useful for whole-body characterization of transgenic Cre mice and to detect previously unknown Cre activity. We anticipate that the Cre-switchable PET reporter mice will be broadly applicable for non-invasive long-term tracking of selected cell populations in vivo.Non-invasive cell tracking is a powerful method to visualize cells in vivo under physiological and pathophysiological conditions. Here Thunemann et al. generate a mouse model for in vivo tracking and quantification of specific cell types by combining a PET reporter gene with Cre-dependent activation that can be exploited for any cell population for which a Cre mouse line is available. Twit Text FOAVip Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28874662 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28874662 #FOAvip English Wikipedia <ref>{{Cite pmid|28874662 }}</ref> Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography #MMPMID28874662 Thunemann M ; Schörg BF ; Feil S ; Lin Y ; Voelkl J ; Golla M ; Vachaviolos A ; Kohlhofer U ; Quintanilla-Martinez L ; Olbrich M ; Ehrlichmann W ; Reischl G ; Griessinger CM ; Langer HF ; Gawaz M ; Lang F ; Schäfers M ; Kneilling M ; Pichler BJ ; Feil R Nat Commun 2017[Sep]; 8 (1 ): 444 PMID28874662 show ga Many pathophysiological processes are associated with proliferation, migration or death of distinct cell populations. Monitoring specific cell types and their progeny in a non-invasive, longitudinal and quantitative manner is still challenging. Here we show a novel cell-tracking system that combines Cre/lox-assisted cell fate mapping with a thymidine kinase (sr39tk) reporter gene for cell detection by positron emission tomography (PET). We generate Rosa26-mT/sr39tk PET reporter mice and induce sr39tk expression in platelets, T lymphocytes or cardiomyocytes. As proof of concept, we demonstrate that our mouse model permits longitudinal PET imaging and quantification of T-cell homing during inflammation and cardiomyocyte viability after myocardial infarction. Moreover, Rosa26-mT/sr39tk mice are useful for whole-body characterization of transgenic Cre mice and to detect previously unknown Cre activity. We anticipate that the Cre-switchable PET reporter mice will be broadly applicable for non-invasive long-term tracking of selected cell populations in vivo.Non-invasive cell tracking is a powerful method to visualize cells in vivo under physiological and pathophysiological conditions. Here Thunemann et al. generate a mouse model for in vivo tracking and quantification of specific cell types by combining a PET reporter gene with Cre-dependent activation that can be exploited for any cell population for which a Cre mouse line is available. |Animals [MESH] |Cell Tracking/*methods [MESH] |Fluorodeoxyglucose F18 [MESH] |Genes, Reporter [MESH] |Inflammation/pathology [MESH] |Integrases/*metabolism [MESH] |Mice [MESH] |Myocardial Infarction/pathology [MESH] |Positron-Emission Tomography/*methods [MESH] |Recombination, Genetic/*genetics [MESH] |T-Lymphocytes/immunology [MESH]Cre/lox-assisted non-invasive in vivo tracking of specific cell popula(epmc).pdf DeepDyve Pubget Overpricing