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10.1080/21541248.2016.1212689 http://scihub22266oqcxt.onion/10.1080/21541248.2016.1212689 C5584735!5584735!27416373     free     free     free       Small+GTPases 2017 ; 8 (3): 187-92 Nephropedia Template TP {{tp|p=27416373|t=2017. What makes oncogenes mutually exclusive?|pdf=|usr=}}{{27416373}} gab.com Text What makes oncogenes mutually exclusive JO: Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=27416373 #FOAvip Cancer is driven by mutations in genes whose products participate in major signaling pathways that fuel cell proliferation and survival. It is easy to assume that the more of these so-called driver mutations a tumor accumulates, the faster it progresses. However, this does not appear to be the case: Data from large-scale genome sequencing studies indicate that mutations in driver oncogenes often are mutually exclusive. The mechanisms underlying the mutual exclusivity of oncogenes are not completely understood, but recent reports suggest that the mechanisms may depend on the tumor type, and the nature of interacting oncogenes. Here we discuss our recent findings that the oncogenes KRASG12D and BRAFV600E are mutually exclusive in lung cancer in mouse models because their coexpression leads to oncogene-induced senescence. Twit Text FOAVip What makes oncogenes mutually exclusive ????Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=27416373 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27416373 #FOAvip English Wikipedia <ref>{{Cite pmid|27416373}}</ref> What makes oncogenes mutually exclusive? #MMPMID27416373 Cisowski J; Bergo MO Small GTPases 2017[]; 8 (3): 187-92 PMID27416373show ga Cancer is driven by mutations in genes whose products participate in major signaling pathways that fuel cell proliferation and survival. It is easy to assume that the more of these so-called driver mutations a tumor accumulates, the faster it progresses. However, this does not appear to be the case: Data from large-scale genome sequencing studies indicate that mutations in driver oncogenes often are mutually exclusive. The mechanisms underlying the mutual exclusivity of oncogenes are not completely understood, but recent reports suggest that the mechanisms may depend on the tumor type, and the nature of interacting oncogenes. Here we discuss our recent findings that the oncogenes KRASG12D and BRAFV600E are mutually exclusive in lung cancer in mouse models because their coexpression leads to oncogene-induced senescence. äWhat makes oncogenes mutually exclusive?(epmc).pdf DeepDyve Pubget Overpricing