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10.1080/21541248.2016.1211398 http://scihub22266oqcxt.onion/10.1080/21541248.2016.1211398 C5584733!5584733 !27442895     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27442895 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Small+GTPases 2017 ; 8 (3 ): 139-163 Nephropedia Template TP {{tp|p=27442895 |t=2017. Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms |pdf=|usr=}}{{27442895 }} gab.com Text Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms JO: Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=27442895 #FOAvip Abnormal Rac1 signaling is linked to a number of debilitating human diseases, including cancer, cardiovascular diseases and neurodegenerative disorders. As such, Rac1 represents an attractive therapeutic target, yet the search for effective Rac1 inhibitors is still underway. Given the adverse effects associated with Rac1 signaling perturbation, cells have evolved several mechanisms to ensure the tight regulation of Rac1 signaling. Thus, characterizing these mechanisms can provide invaluable information regarding major cellular events that lead to aberrant Rac1 signaling. Importantly, this information can be utilized to further facilitate the development of effective pharmacological modulators that can restore normal Rac1 signaling. In this review, we focus on the pathological role of Rac1 signaling, highlighting the benefits and potential drawbacks of targeting Rac1 in a clinical setting. Additionally, we provide an overview of available compounds that target key Rac1 regulatory mechanisms and discuss future therapeutic avenues arising from our understanding of these mechanisms. Twit Text FOAVip Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms ????Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=27442895 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27442895 #FOAvip English Wikipedia <ref>{{Cite pmid|27442895 }}</ref> Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms #MMPMID27442895 Marei H ; Malliri A Small GTPases 2017[Jul]; 8 (3 ): 139-163 PMID27442895 show ga Abnormal Rac1 signaling is linked to a number of debilitating human diseases, including cancer, cardiovascular diseases and neurodegenerative disorders. As such, Rac1 represents an attractive therapeutic target, yet the search for effective Rac1 inhibitors is still underway. Given the adverse effects associated with Rac1 signaling perturbation, cells have evolved several mechanisms to ensure the tight regulation of Rac1 signaling. Thus, characterizing these mechanisms can provide invaluable information regarding major cellular events that lead to aberrant Rac1 signaling. Importantly, this information can be utilized to further facilitate the development of effective pharmacological modulators that can restore normal Rac1 signaling. In this review, we focus on the pathological role of Rac1 signaling, highlighting the benefits and potential drawbacks of targeting Rac1 in a clinical setting. Additionally, we provide an overview of available compounds that target key Rac1 regulatory mechanisms and discuss future therapeutic avenues arising from our understanding of these mechanisms. |*Signal Transduction/drug effects [MESH] |Animals [MESH] |Enzyme Activation/drug effects [MESH] |Humans [MESH] |Molecular Targeted Therapy/*methods [MESH] |Nucleotides/metabolism [MESH]Rac1 in human diseases: The therapeutic potential of targeting Rac1 si(epmc).pdf DeepDyve Pubget Overpricing