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10.1073/pnas.1710336114 http://scihub22266oqcxt.onion/10.1073/pnas.1710336114 C5584459!5584459 !28808019     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28808019 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (35 ): 9397-9402 Nephropedia Template TP {{tp|p=28808019 |t=2017. Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype |pdf=|usr=}}{{28808019 }} gab.com Text Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28808019 #FOAvip In host-pathogen arms races, increases in host resistance prompt counteradaptation by pathogens, but the nature of that counteradaptation is seldom directly observed outside of laboratory models. The best-documented field example is the coevolution of myxoma virus (MYXV) in European rabbits. To understand how MYXV in Australia has continued to evolve in wild rabbits under intense selection for genetic resistance to myxomatosis, we compared the phenotypes of the progenitor MYXV and viral isolates from the 1950s and the 1990s in laboratory rabbits with no resistance. Strikingly, and unlike their 1950s counterparts, most virus isolates from the 1990s induced a highly lethal immune collapse syndrome similar to septic shock. Thus, the next step in this canonical case of coevolution after a species jump has been further escalation by the virus in the face of widespread host resistance. Twit Text FOAVip Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28808019 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28808019 #FOAvip English Wikipedia <ref>{{Cite pmid|28808019 }}</ref> Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype #MMPMID28808019 Kerr PJ ; Cattadori IM ; Liu J ; Sim DG ; Dodds JW ; Brooks JW ; Kennett MJ ; Holmes EC ; Read AF Proc Natl Acad Sci U S A 2017[Aug]; 114 (35 ): 9397-9402 PMID28808019 show ga In host-pathogen arms races, increases in host resistance prompt counteradaptation by pathogens, but the nature of that counteradaptation is seldom directly observed outside of laboratory models. The best-documented field example is the coevolution of myxoma virus (MYXV) in European rabbits. To understand how MYXV in Australia has continued to evolve in wild rabbits under intense selection for genetic resistance to myxomatosis, we compared the phenotypes of the progenitor MYXV and viral isolates from the 1950s and the 1990s in laboratory rabbits with no resistance. Strikingly, and unlike their 1950s counterparts, most virus isolates from the 1990s induced a highly lethal immune collapse syndrome similar to septic shock. Thus, the next step in this canonical case of coevolution after a species jump has been further escalation by the virus in the face of widespread host resistance. |Animals [MESH] |Australia/epidemiology [MESH] |Biological Evolution [MESH] |Myxoma virus/*genetics/pathogenicity [MESH] |Poxviridae Infections/epidemiology/pathology/*veterinary [MESH] |Rabbits/*virology [MESH] |Time Factors [MESH] |Tumor Virus Infections/epidemiology/pathology/*veterinary [MESH]Next step in the ongoing arms race between myxoma virus and wild rabbi(epmc).pdf DeepDyve Pubget Overpricing