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10.1073/pnas.1707032114 http://scihub22266oqcxt.onion/10.1073/pnas.1707032114 C5584439!5584439!28808028     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28808028&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (35): 9439-44 Nephropedia Template TP {{tp|p=28808028|t=2017. Immune evasion by a staphylococcal inhibitor of myeloperoxidase |pdf=|usr=}}{{28808028}} gab.com Text Immune evasion by a staphylococcal inhibitor of myeloperoxidase JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28808028 #FOAvip Staphylococcus aureus secretes numerous proteins to evade our innate immune system, for example to evade opsonization and phagocytosis by neutrophils. Here we describe the discovery that S. aureus has evolved a protein, called SPIN, that specifically binds and inhibits the human myeloperoxidase enzyme (MPO). MPO is located inside the granules of neutrophils and is important in the oxidative burst against pathogens. We identify the molecular mode of action of SPIN inhibiting MPO, illustrate this with the cocrystal structure, and show that SPIN is important for bacterial survival by MPO-dependent killing. Our study shows that S. aureus fights back after it is engulfed by neutrophils, which will help our understanding of the complex nature of S. aureus infections. Twit Text FOAVip Immune evasion by a staphylococcal inhibitor of myeloperoxidase ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28808028 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28808028 #FOAvip English Wikipedia <ref>{{Cite pmid|28808028}}</ref> Immune evasion by a staphylococcal inhibitor of myeloperoxidase #MMPMID28808028 de Jong NWM; Ramyar KX; Guerra FE; Nijland R; Fevre C; Voyich JM; McCarthy AJ; Garcia BL; van Kessel KPM; van Strijp JAG; Geisbrecht BV; Haas PJA Proc Natl Acad Sci U S A 2017[Aug]; 114 (35): 9439-44 PMID28808028show ga Staphylococcus aureus secretes numerous proteins to evade our innate immune system, for example to evade opsonization and phagocytosis by neutrophils. Here we describe the discovery that S. aureus has evolved a protein, called SPIN, that specifically binds and inhibits the human myeloperoxidase enzyme (MPO). MPO is located inside the granules of neutrophils and is important in the oxidative burst against pathogens. We identify the molecular mode of action of SPIN inhibiting MPO, illustrate this with the cocrystal structure, and show that SPIN is important for bacterial survival by MPO-dependent killing. Our study shows that S. aureus fights back after it is engulfed by neutrophils, which will help our understanding of the complex nature of S. aureus infections. äImmune evasion by a staphylococcal inhibitor of myeloperoxidase (epmc).pdf DeepDyve Pubget Overpricing