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2017 ; 2017
(ä): 6167345
Nephropedia Template TP
gab.com Text
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English Wikipedia
Ponatinib as a Valid Alternative Strategy in Patients with Blast Crisis-Chronic
Myeloid Leukemia Not Eligible for Allogeneic Stem Cells Transplantation and/or
Conventional Chemotherapy: Report of a Case
#MMPMID28890835
Bucelli C
; Cattaneo D
; Ferla V
; Zappa M
; de Benedittis C
; Soverini S
; Iurlo A
Case Rep Hematol
2017[]; 2017
(ä): 6167345
PMID28890835
show ga
Currently, imatinib and dasatinib are the only tyrosine-kinase inhibitors
approved in the US and Europe for the treatment of blast crisis of chronic
myeloid leukemia (BC-CML) at diagnosis, while ponatinib is the only inhibitor
used in patients bearing T315I mutation. Here we report the case of a 61-year-old
man diagnosed with B-cell lymphoid BC-CML, initially treated with imatinib 800?mg
day and then with dasatinib 140?mg day because of intolerance. A complete
cytogenetic response (CCyR) was achieved at three months; however, three months
later a relapse was observed, and the T315I mutation was detected. Ponatinib
45?mg once daily was then started together with a short course of chemotherapy.
Bone marrow evaluation after six months of therapy showed the regaining of CCyR,
together with the achievement of a deep molecular response. However, one year
from ponatinib start the patient experienced a new disease relapse; he was
effectively treated with ponatinib and chemotherapy once again, but in the
meanwhile an ischemic stroke was detected. This case report confirms the high
efficacy of ponatinib monotherapy in BC-CML patients, representing a valid option
for non-allogeneic stem cells transplantation eligible cases and the only one
available for those carrying the T315I mutation.