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10.18632/oncotarget.17583 http://scihub22266oqcxt.onion/10.18632/oncotarget.17583 C5584305!5584305!28881704     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (31): 51970-85 Nephropedia Template TP {{tp|p=28881704|t=2017. Chaperone-mediated autophagy substrate proteins in cancer |pdf=|usr=}}{{28881704}} gab.com Text Chaperone-mediated autophagy substrate proteins in cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28881704 #FOAvip All intracellular proteins undergo continuous synthesis and degradation. Chaperone-mediated autophagy (CMA) is necessary to maintain cellular homeostasis through turnover of cytosolic proteins (substrate proteins). This degradation involves a series of substrate proteins including both cancer promoters and suppressors. Since activating or inhibiting CMA pathway to treat cancer is still debated, targeting to the CMA substrate proteins provides a novel direction. We summarize the cancer-associated substrate proteins which are degraded by CMA. Consequently, CMA substrate proteins catalyze the glycolysis which contributes to the Warburg effect in cancer cells. The fact that the degradation of substrate proteins based on the CMA can be altered by posttranslational modifications such as phosphorylation or acetylation. In conclusion, targeting to CMA substrate proteins develops into a new anticancer therapeutic approach. Twit Text FOAVip Chaperone-mediated autophagy substrate proteins in cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28881704 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28881704 #FOAvip English Wikipedia <ref>{{Cite pmid|28881704}}</ref> Chaperone-mediated autophagy substrate proteins in cancer #MMPMID28881704 Tang Y; Wang XW; Liu ZH; Sun YM; Tang YX; Zhou DH Oncotarget 2017[Aug]; 8 (31): 51970-85 PMID28881704show ga All intracellular proteins undergo continuous synthesis and degradation. Chaperone-mediated autophagy (CMA) is necessary to maintain cellular homeostasis through turnover of cytosolic proteins (substrate proteins). This degradation involves a series of substrate proteins including both cancer promoters and suppressors. Since activating or inhibiting CMA pathway to treat cancer is still debated, targeting to the CMA substrate proteins provides a novel direction. We summarize the cancer-associated substrate proteins which are degraded by CMA. Consequently, CMA substrate proteins catalyze the glycolysis which contributes to the Warburg effect in cancer cells. The fact that the degradation of substrate proteins based on the CMA can be altered by posttranslational modifications such as phosphorylation or acetylation. In conclusion, targeting to CMA substrate proteins develops into a new anticancer therapeutic approach. äChaperone-mediated autophagy substrate proteins in cancer (epmc).pdf DeepDyve Pubget Overpricing