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10.1084/jem.20162040

http://scihub22266oqcxt.onion/10.1084/jem.20162040
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C5584123!5584123!28716882
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suck abstract from ncbi


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pmid28716882      J+Exp+Med 2017 ; 214 (9): 2671-93
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  • Protein kinase D at the Golgi controls NLRP3 inflammasome activation #MMPMID28716882
  • Zhang Z; Meszaros G; He Wt; Xu Y; de Fatima Magliarelli H; Mailly L; Mihlan M; Liu Y; Puig Gámez M; Goginashvili A; Pasquier A; Bielska O; Neven B; Quartier P; Aebersold R; Baumert TF; Georgel P; Han J; Ricci R
  • J Exp Med 2017[Sep]; 214 (9): 2671-93 PMID28716882show ga
  • Zhang et al. show that Golgi-mediated protein kinase D (PKD) signaling is required and sufficient for NLRP3 inflammasome activation. PKD at the Golgi phosphorylates NLRP3 to release it from mitochondria-associated endoplasmic reticulum membranes, allowing for assembly of the mature inflammasome in the cytosol.
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