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10.1084/jem.20161160

http://scihub22266oqcxt.onion/10.1084/jem.20161160
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C5584115!5584115!28847869
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suck abstract from ncbi


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pmid28847869      J+Exp+Med 2017 ; 214 (9): 2573-90
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  • Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo #MMPMID28847869
  • Medina-Ramírez M; Garces F; Escolano A; Skog P; de Taeye SW; Del Moral-Sanchez I; McGuire AT; Yasmeen A; Behrens AJ; Ozorowski G; van den Kerkhof TL; Freund NT; Dosenovic P; Hua Y; Gitlin AD; Cupo A; van der Woude P; Golabek M; Sliepen K; Blane T; Kootstra N; van Breemen MJ; Pritchard LK; Stanfield RL; Crispin M; Ward AB; Stamatatos L; Klasse PJ; Moore JP; Nemazee D; Nussenzweig MC; Wilson IA; Sanders RW
  • J Exp Med 2017[Sep]; 214 (9): 2573-90 PMID28847869show ga
  • Induction of broadly neutralizing antibodies (bNAbs) to HIV would be a major advance toward an effective vaccine. A critical step in this process is the activation of naive B cells expressing bNAb precursors. Medina-Ramírez et al. developed a BG505 SOSIP.v4.1-GT1 trimer that activates bNAb precursors in vitro and in vivo.
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