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10.1084/jem.20161134 http://scihub22266oqcxt.onion/10.1084/jem.20161134 C5584114!5584114 !28765400     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28765400 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2017 ; 214 (9 ): 2591-2610 Nephropedia Template TP {{tp|p=28765400 |t=2017. Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism |pdf=|usr=}}{{28765400 }} gab.com Text Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=28765400 #FOAvip Although a large proportion of patients with type 2 diabetes (T2D) accumulate misfolded aggregates composed of the islet amyloid polypeptide (IAPP), its role in the disease is unknown. Here, we show that pancreatic IAPP aggregates can promote the misfolding and aggregation of endogenous IAPP in islet cultures obtained from transgenic mouse or healthy human pancreas. Islet homogenates immunodepleted with anti-IAPP-specific antibodies were not able to induce IAPP aggregation. Importantly, intraperitoneal inoculation of pancreatic homogenates containing IAPP aggregates into transgenic mice expressing human IAPP dramatically accelerates IAPP amyloid deposition, which was accompanied by clinical abnormalities typical of T2D, including hyperglycemia, impaired glucose tolerance, and a substantial reduction on ? cell number and mass. Finally, induction of IAPP deposition and diabetic abnormalities were also induced in vivo by administration of IAPP aggregates prepared in vitro using pure, synthetic IAPP. Our findings suggest that some of the pathologic and clinical alterations of T2D might be transmissible through a similar mechanism by which prions propagate in prion diseases. Twit Text FOAVip Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=28765400 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28765400 #FOAvip English Wikipedia <ref>{{Cite pmid|28765400 }}</ref> Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism #MMPMID28765400 Mukherjee A ; Morales-Scheihing D ; Salvadores N ; Moreno-Gonzalez I ; Gonzalez C ; Taylor-Presse K ; Mendez N ; Shahnawaz M ; Gaber AO ; Sabek OM ; Fraga DW ; Soto C J Exp Med 2017[Sep]; 214 (9 ): 2591-2610 PMID28765400 show ga Although a large proportion of patients with type 2 diabetes (T2D) accumulate misfolded aggregates composed of the islet amyloid polypeptide (IAPP), its role in the disease is unknown. Here, we show that pancreatic IAPP aggregates can promote the misfolding and aggregation of endogenous IAPP in islet cultures obtained from transgenic mouse or healthy human pancreas. Islet homogenates immunodepleted with anti-IAPP-specific antibodies were not able to induce IAPP aggregation. Importantly, intraperitoneal inoculation of pancreatic homogenates containing IAPP aggregates into transgenic mice expressing human IAPP dramatically accelerates IAPP amyloid deposition, which was accompanied by clinical abnormalities typical of T2D, including hyperglycemia, impaired glucose tolerance, and a substantial reduction on ? cell number and mass. Finally, induction of IAPP deposition and diabetic abnormalities were also induced in vivo by administration of IAPP aggregates prepared in vitro using pure, synthetic IAPP. Our findings suggest that some of the pathologic and clinical alterations of T2D might be transmissible through a similar mechanism by which prions propagate in prion diseases. |Animals [MESH] |Diabetes Mellitus, Type 2/etiology/*metabolism/pathology [MESH] |Female [MESH] |Humans [MESH] |Islet Amyloid Polypeptide/*metabolism [MESH] |Islets of Langerhans/*metabolism/pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Prions/metabolism [MESH] |Protein Aggregates [MESH]Induction of IAPP amyloid deposition and associated diabetic abnormali(epmc).pdf DeepDyve Pubget Overpricing