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10.1084/jem.20160999

http://scihub22266oqcxt.onion/10.1084/jem.20160999
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C5584112!5584112!28778989
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suck abstract from ncbi


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pmid28778989      J+Exp+Med 2017 ; 214 (9): 2611-28
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  • Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation #MMPMID28778989
  • Chang MC; Srinivasan K; Friedman BA; Suto E; Modrusan Z; Lee WP; Kaminker JS; Hansen DV; Sheng M
  • J Exp Med 2017[Sep]; 214 (9): 2611-28 PMID28778989show ga
  • It is unclear how progranulin deficiency causes frontotemporal dementia, a neurodegenerative disease characterized by TDP-43 inclusions. Chang et al. show that loss of progranulin causes impairment of autophagy and autophagy signaling, which leads to accumulation of pathological TDP-43 in neurons.
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