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10.1038/ng.3531 http://scihub22266oqcxt.onion/10.1038/ng.3531 C5584070!5584070!26998692     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Genet 2016 ; 48 (5): 519-27 Nephropedia Template TP {{tp|p=26998692|t=2016. Genetic Predisposition for Beta Cell Fragility Underlies Type 1 and Type 2 Diabetes |pdf=|usr=}}{{26998692}} gab.com Text Genetic Predisposition for Beta Cell Fragility Underlies Type 1 and Type 2 Diabetes JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=26998692 #FOAvip Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure inT2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell fragility. Genetic variation in Xrcc4 and Glis3 alters the response of NOD beta cells to unfolded protein stress, enhancing the apoptotic and senescent fates. The same transcriptional relationships were observed in human islets, demonstrating the role of beta cell fragility in genetic predisposition to diabetes. Twit Text FOAVip Genetic Predisposition for Beta Cell Fragility Underlies Type 1 and Type 2 Diabetes ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=26998692 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26998692 #FOAvip English Wikipedia <ref>{{Cite pmid|26998692}}</ref> Genetic Predisposition for Beta Cell Fragility Underlies Type 1 and Type 2 Diabetes #MMPMID26998692 Dooley J; Tian L; Schonefeldt S; Delghingaro-Augusto V; Garcia-Perez JE; Pasciuto E; Di Marino D; Carr EJ; Oskolkov N; Lyssenko V; Franckaert D; Lagou V; Overbergh L; Vandenbussche J; Allemeersch J; Chabot-Roy G; Dahlstrom JE; Laybutt DR; Petrovsky N; Socha L; Gevaert K; Jetten AM; Lambrechts D; Linterman MA; Goodnow CC; Nolan CJ; Lesage S; Schlenner SM; Liston A Nat Genet 2016[May]; 48 (5): 519-27 PMID26998692show ga Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure inT2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell fragility. Genetic variation in Xrcc4 and Glis3 alters the response of NOD beta cells to unfolded protein stress, enhancing the apoptotic and senescent fates. The same transcriptional relationships were observed in human islets, demonstrating the role of beta cell fragility in genetic predisposition to diabetes. äGenetic Predisposition for Beta Cell Fragility Underlies Type 1 and Ty(epmc).pdf DeepDyve Pubget Overpricing