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2017 ; 3
(3
): FSO201
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Catabolic and anabolic faces of insulin resistance and their disorders: a new
insight into circadian control of metabolic disorders leading to diabetes
#MMPMID28884000
Schwartsburd PM
Future Sci OA
2017[Aug]; 3
(3
): FSO201
PMID28884000
show ga
Maintenance of glucose homeostasis during circadian behavioral cycles is
critical. The processes controlling the switch between predominant
lipolysis/fatty oxidation during fasting and predominant lipid storage/glucose
oxidation following feeding are determined principally by insulin. Chronic
elevated threshold of insulin resistance (IR) is a key pathological feature of
obesity, Type 2 diabetes, sepsis and cancer cachexia; however, a temporal reduced
threshold of IR is widely met in fasting/hibernation, pregnancy, antibacterial
immunity, exercise and stress. Paradoxically, some of these cases are associated
with catabolic metabolism, whereas others are related to anabolic pathways. This
article considers the possible causes of circadian disorders in glucose and lipid
metabolism that act as a driving force for obesity-promoted development of Type 2
diabetes. This is intended to provide improved insight into the pathogenesis of
chronic circadian disorders that increase the risk of diabetes, and consider new
targets for its metabolic and drug correction.