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2017 ; 6
(8
): e77
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Zika virus infects renal proximal tubular epithelial cells with prolonged
persistency and cytopathic effects
#MMPMID28831192
Chen J
; Yang YF
; Chen J
; Zhou X
; Dong Z
; Chen T
; Yang Y
; Zou P
; Jiang B
; Hu Y
; Lu L
; Zhang X
; Liu J
; Xu J
; Zhu T
Emerg Microbes Infect
2017[Aug]; 6
(8
): e77
PMID28831192
show ga
Zika virus (ZIKV) infection can cause fetal developmental abnormalities and
Guillain-Barré syndrome in adults. Although progress has been made in
understanding the link between ZIKV infection and microcephaly, the pathology of
ZIKV, particularly the viral reservoirs in human, remains poorly understood.
Several studies have shown that compared to serum samples, patients' urine
samples often have a longer duration of ZIKV persistency and higher viral load.
This finding suggests that an independent viral reservoir may exist in the human
urinary system. Despite the clinical observations, the host cells of ZIKV in the
human urinary system are poorly characterized. In this study, we demonstrate that
ZIKV can infect renal proximal tubular epithelial cells (RPTEpiCs) in
immunodeficient mice in vivo and in both immortalized and primary human renal
proximal tubular epithelial cells (hRPTEpiCs) in vitro. Importantly, ZIKV
infection in mouse kidneys caused caspase-3-mediated apoptosis of renal cells.
Similarly, in vitro infection of immortalized and primary hRPTEpiCs resulted in
notable cytopathic effects. Consistent with the clinical observations, we found
that ZIKV infection can persist with prolonged duration in hRPTEpiCs. RNA-Seq
analyses of infected hRPTEpiCs revealed a large number of transcriptional changes
in response to ZIKV infection, including type I interferon signaling genes and
anti-viral response genes. Our results suggest that hRPTEpiCs are a potential
reservoir of ZIKV in the human urinary system, providing a possible explanation
for the prolonged persistency of ZIKV in patients' urine.
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