Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28928910
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 World+J+Stem+Cells
2017 ; 9
(8
): 133-143
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Phase I/II randomized controlled trial of autologous bone marrow-derived
mesenchymal stem cell therapy for chronic stroke
#MMPMID28928910
Tsang KS
; Ng CPS
; Zhu XL
; Wong GKC
; Lu G
; Ahuja AT
; Wong KSL
; Ng HK
; Poon WS
World J Stem Cells
2017[Aug]; 9
(8
): 133-143
PMID28928910
show ga
AIM: To examine the safety and efficacy of mesenchymal stem cell (MSC) therapy
for intracerebral haemorrhage with neurological dysfunctions for a year. METHODS:
MSC were ex vivo expanded from 29 mL (17-42 mL) autologous bone marrow. Patients
were randomized to have two intravenous injections of autologous MSC or placebos
in four weeks apart. Neurological functions and clinical outcomes were monitored
before treatment and at 12(th), 16(th), 24(th), 36(th) and 60(th) week upon
completion of the treatment. RESULTS: A mean of 4.57 × 10(7) (range: 1.43 ×
10(7)-8.40 × 10(7)) MSC per infusion was administered accounting to 8.54 × 10(5)
(2.65 × 10(5)-1.45 × 10(6)) per kilogram body weight in two occasions. There was
neither adverse event at time of administration nor sign of de novo tumour
development among patients after monitoring for a year post MSC therapy.
Neuro-restoration and clinical improvement in terms of modified Barthel index,
functional independence measure and extended Glasgow Outcome Scale were evident
among patients having MSC therapy compared to patients receiving placebos.
CONCLUSION: Intravenous administration of autologous bone marrow-derived MSC is
safe and has the potential of improving neurological functions in chronic stroke
patients with severe disability.