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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Kidney+Cancer+VHL
2017 ; 4
(3
): 30-36
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Functional Imaging of Paragangliomas with an Emphasis on Von
Hippel-Lindau-Associated Disease: A Mini Review
#MMPMID28890865
Ilias I
; Meristoudis G
J Kidney Cancer VHL
2017[]; 4
(3
): 30-36
PMID28890865
show ga
Few reports have presented data and results on functional (i.e., nuclear
medicine) imaging of paragangliomas and pheochromocytomas (PGLs/PHEOs) for von
Hippel-Lindau (VHL) patients. Nuclear medicine localization modalities for
chromaffin tumors can be specific or nonspecific. Specific methods make use of
the expression of the human norepinephrine transporter (hNET) and vesicular
monoamine transporters (VMATs) by these tumors. These permit the use of
radiolabeled ligands that enter the synthesis and storage pathway of
catecholamines. Nonspecific methods are not related to the synthesis, uptake, or
storage of catecholamines but make use of the tumors' high glucose metabolism or
expression of somatostatin receptors. Consensuses and guidelines suggest that
metastatic and sporadic PHEOs/PGLs in VHL patients (as in patients with
chromaffin tumors of yet unknown genotype) should be evaluated first with
(18)F-dihydroxyphenylalanine ((18)F-DOPA) positron emission tomography/computed
tomography (PET/CT). The functional imaging of second choice is
(123)I-metaiodobenzylguanidine ((123)I-MIBG) for PHEOs in VHL patients.
(123)I-MIBG, (68)Ga-DOTATATE/DOTATOC/DOTANOC PET/CT, or (18)F-fluorodeoxyglucose
((18)F-FDG) PET/CT can be a second choice of functional imaging for PGLs in VHL
patients.