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10.2119/molmed.2016.00243 http://scihub22266oqcxt.onion/10.2119/molmed.2016.00243 C5583065!5583065!28620671     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Med 2017 ; 23 (ä): 166-76 Nephropedia Template TP {{tp|p=28620671|t=2017. An Oligodeoxynucleotide with AAAG Repeats Significantly Attenuates Burn-Induced Systemic Inflammatory Responses by Inhibiting Interferon Regulatory Factor 5 Pathway |pdf=|usr=}}{{28620671}} gab.com Text An Oligodeoxynucleotide with AAAG Repeats Significantly Attenuates Burn-Induced Systemic Inflammatory Responses by Inhibiting Interferon Regulatory Factor 5 Pathway JO: Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28620671 #FOAvip Previously, we showed that an oligodeoxynucleotide (ODN) with AAAG repeats (AAAG ODN) rescued mice from fatal acute lung injury (ALI) induced by influenza virus and inhibited production of tumor necrosis factor-? (TNF-?) in the injured lungs. However, its underlying mechanisms remain to be elucidated. Upon the bioinformatic analysis revealing that the sequence of AAAG ODN is in consensus with the interferon regulatory factor 5 (IRF5) binding site in the cis-regulatory elements of proinflammatory cytokines, we tried to explore whether AAAG ODN could attenuate burn injury?induced systemic inflammatory responses by inhibiting the IRF5 pathway. Using a mouse model with sterile systemic inflammation induced by burn injury, we found that AAAG ODN prolonged the lifespan of the mice, decreased the expression of IRF5 in the injured skin, reduced the production of TNF-? and IL-6 in the blood and injured skin, and attenuated the ALI. These effects were correlated with AAAG ODN?mediated inhibition of nuclear translocation of IRF5. The data suggest that AAAG ODN could act as a cytoplasmic decoy capable of interfering the function of IRF5 and be developed as a drug candidate for the treatment of inflammatory diseases. Twit Text FOAVip An Oligodeoxynucleotide with AAAG Repeats Significantly Attenuates Burn-Induced Systemic Inflammatory Responses by Inhibiting Interferon Regulatory Factor 5 Pathway ????Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28620671 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28620671 #FOAvip English Wikipedia <ref>{{Cite pmid|28620671}}</ref> An Oligodeoxynucleotide with AAAG Repeats Significantly Attenuates Burn-Induced Systemic Inflammatory Responses by Inhibiting Interferon Regulatory Factor 5 Pathway #MMPMID28620671 Xiao Y; Lu W; Li X; Zhao P; Yao Y; Wang X; Wang Y; Lin Z; Yu Y; Hua S; Wang L Mol Med 2017[]; 23 (ä): 166-76 PMID28620671show ga Previously, we showed that an oligodeoxynucleotide (ODN) with AAAG repeats (AAAG ODN) rescued mice from fatal acute lung injury (ALI) induced by influenza virus and inhibited production of tumor necrosis factor-? (TNF-?) in the injured lungs. However, its underlying mechanisms remain to be elucidated. Upon the bioinformatic analysis revealing that the sequence of AAAG ODN is in consensus with the interferon regulatory factor 5 (IRF5) binding site in the cis-regulatory elements of proinflammatory cytokines, we tried to explore whether AAAG ODN could attenuate burn injury?induced systemic inflammatory responses by inhibiting the IRF5 pathway. Using a mouse model with sterile systemic inflammation induced by burn injury, we found that AAAG ODN prolonged the lifespan of the mice, decreased the expression of IRF5 in the injured skin, reduced the production of TNF-? and IL-6 in the blood and injured skin, and attenuated the ALI. These effects were correlated with AAAG ODN?mediated inhibition of nuclear translocation of IRF5. The data suggest that AAAG ODN could act as a cytoplasmic decoy capable of interfering the function of IRF5 and be developed as a drug candidate for the treatment of inflammatory diseases. äAn Oligodeoxynucleotide with AAAG Repeats Significantly Attenuates Bur(epmc).pdf DeepDyve Pubget Overpricing