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10.2119/molmed.2016.00243 http://scihub22266oqcxt.onion/10.2119/molmed.2016.00243 C5583065!5583065 !28620671     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28620671 &cmd=llinks): Failed to open stream: HTTP request failed! 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An oligodeoxynucleotide with AAAG repeats significantly attenuates burn-induced systemic inflammatory responses via inhibiting interferon regulatory factor 5 pathway |pdf=|usr=}}{{28620671 }} gab.com Text An oligodeoxynucleotide with AAAG repeats significantly attenuates burn-induced systemic inflammatory responses via inhibiting interferon regulatory factor 5 pathway JO: Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28620671 #FOAvip Previously, we showed that an oligodeoxynucleotide with AAAG repeats (AAAG ODN) rescued mice from fatal acute lung injury (ALI) induced by influenza virus and inhibited production of tumor necrosis factor-? (TNF-?) in the injured lungs. However, the underlying mechanisms remain to be elucidated. Upon the bioinformatic analysis revealing that the AAAG ODN is consensus to interferon regulatory factor 5 (IRF5) binding site in the cis-regulatory elements of proinflammatory cytokines, we tried to explore whether the AAAG ODN could attenuate burn injury induced systemic inflammatory responses via inhibiting IRF5 pathway. Using the mouse model with sterile systemic inflammation induced by burn injury, we found that AAAG ODN prolonged the life span of the mice, decreased the expression of IRF5 at injured skin, reduced the production of TNF-? and IL-6 in blood and injured skin, and attenuated the ALI. Furthermore, AAAG ODN could bind IRF5 and inhibit the nuclear translocation of IRF5 in THP-1 cells. The data suggested that the AAAG ODN could act as a cytoplasmic decoy capable of interfering the function of IRF5, and be developed as a drug candidate for the treatment of inflammatory diseases. Twit Text FOAVip An oligodeoxynucleotide with AAAG repeats significantly attenuates burn-induced systemic inflammatory responses via inhibiting interferon regulatory factor 5 pathway ????Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28620671 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28620671 #FOAvip English Wikipedia <ref>{{Cite pmid|28620671 }}</ref> An oligodeoxynucleotide with AAAG repeats significantly attenuates burn-induced systemic inflammatory responses via inhibiting interferon regulatory factor 5 pathway #MMPMID28620671 Xiao Y ; Lu W ; Li X ; Zhao P ; Yao Y ; Wang X ; Wang Y ; Lin Z ; Yu Y ; Hua S ; Wang L Mol Med 2017[Sep]; 23 (ä): 166-176 PMID28620671 show ga Previously, we showed that an oligodeoxynucleotide with AAAG repeats (AAAG ODN) rescued mice from fatal acute lung injury (ALI) induced by influenza virus and inhibited production of tumor necrosis factor-? (TNF-?) in the injured lungs. However, the underlying mechanisms remain to be elucidated. Upon the bioinformatic analysis revealing that the AAAG ODN is consensus to interferon regulatory factor 5 (IRF5) binding site in the cis-regulatory elements of proinflammatory cytokines, we tried to explore whether the AAAG ODN could attenuate burn injury induced systemic inflammatory responses via inhibiting IRF5 pathway. Using the mouse model with sterile systemic inflammation induced by burn injury, we found that AAAG ODN prolonged the life span of the mice, decreased the expression of IRF5 at injured skin, reduced the production of TNF-? and IL-6 in blood and injured skin, and attenuated the ALI. Furthermore, AAAG ODN could bind IRF5 and inhibit the nuclear translocation of IRF5 in THP-1 cells. The data suggested that the AAAG ODN could act as a cytoplasmic decoy capable of interfering the function of IRF5, and be developed as a drug candidate for the treatment of inflammatory diseases. |Acute Lung Injury/*drug therapy/etiology/immunology [MESH] |Animals [MESH] |Anti-Inflammatory Agents/pharmacology/*therapeutic use [MESH] |Burns/complications/*drug therapy/immunology [MESH] |Cell Line [MESH] |Female [MESH] |Humans [MESH] |Interferon Regulatory Factors/*antagonists & inhibitors/immunology [MESH] |Interleukin-6/immunology [MESH] |Mice, Inbred BALB C [MESH] |Oligodeoxyribonucleotides/pharmacology/*therapeutic use [MESH] |Systemic Inflammatory Response Syndrome/*drug therapy/etiology/immunology [MESH]An oligodeoxynucleotide with AAAG repeats significantly attenuates bur(epmc).pdf DeepDyve Pubget Overpricing