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10.1038/ni.3646 http://scihub22266oqcxt.onion/10.1038/ni.3646 C5582804!5582804!27992401     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2017 ; 18 (2): 173-83 Nephropedia Template TP {{tp|p=27992401|t=2017. Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment |pdf=|usr=}}{{27992401}} gab.com Text Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27992401 #FOAvip Most Foxp3+ regulatory T (Treg) cells develop in the thymus as a functionally mature T cell subpopulation specialized for immune suppression. Their cell fate appears to be determined before Foxp3 expression; yet molecular events that prime Foxp3? Treg precursor cells are largely obscure. We found that Treg cell?specific super-enhancers (Treg-SEs), which were associated with Foxp3 and other Treg cell signature genes, began to be activated in Treg precursor cells. T cell?specific deficiency of the genome organizer Satb1 impaired Treg-SE activation and the subsequent expression of Treg signature genes, causing severe autoimmunity due to Treg cell deficiency. These results suggest that Satb1-dependent Treg-SE activation is crucial for Treg cell lineage specification in the thymus and that its perturbation is causative of autoimmune and other immunological diseases. Twit Text FOAVip Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27992401 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27992401 #FOAvip English Wikipedia <ref>{{Cite pmid|27992401}}</ref> Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment #MMPMID27992401 Kitagawa Y; Ohkura N; Kidani Y; Vandenbon A; Hirota K; Kawakami R; Yasuda K; Motooka D; Nakamura S; Kondo M; Taniuchi I; Kohwi-Shigematsu T; Sakaguchi S Nat Immunol 2017[Feb]; 18 (2): 173-83 PMID27992401show ga Most Foxp3+ regulatory T (Treg) cells develop in the thymus as a functionally mature T cell subpopulation specialized for immune suppression. Their cell fate appears to be determined before Foxp3 expression; yet molecular events that prime Foxp3? Treg precursor cells are largely obscure. We found that Treg cell?specific super-enhancers (Treg-SEs), which were associated with Foxp3 and other Treg cell signature genes, began to be activated in Treg precursor cells. T cell?specific deficiency of the genome organizer Satb1 impaired Treg-SE activation and the subsequent expression of Treg signature genes, causing severe autoimmunity due to Treg cell deficiency. These results suggest that Satb1-dependent Treg-SE activation is crucial for Treg cell lineage specification in the thymus and that its perturbation is causative of autoimmune and other immunological diseases. äGuidance of regulatory T cell development by Satb1-dependent super-enh(epmc).pdf DeepDyve Pubget Overpricing